2013 Fiscal Year Final Research Report

Effects of exercise training and L-arginine adminstration on fibrinolysis

Research Project

Project/Area Number	22500661
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Applied health science
Research Institution	Nagoya Institute of Technology
Principal Investigator	OHKUWA Tetsuo 名古屋工業大学, 工学(系)研究科(研究院), 教授 (80115675)
Project Period (FY)	2010-04-01 – 2014-03-31
Keywords	アルギニン摂取 / 運動トレーニング / 血液凝固 / 線溶 / 加齢 / 肥満 / 糖尿病 / 酸化ストレス
Research Abstract	The present study was performed to evaluate the effects of exercise training and L-arginine administration on the fibrinolysis, blood coagulation and oxidative stress in aged, obese and diabetic rats. The plasminogen activated factor (t-PA and u-PA) significantly increased after exercise training and L-arginine administration. Moreover, thromboxane B2 increased significantly increased after exercise training and L-arginine administration compared with the control rats. The protein oxidation and lipid peroxide significantly decreased, and reduced glutathione (GSH) and glutathione reductase significantly increased after exercise training and L-arginine administration compared with the control rats. This study confirmed that the exercise training and L-arginine administration improved plasminogen activated factor (t-PA and u-PA) and blood coagulation might be due to decrease in oxidative stress in aged, obese and diabetic rats.

(5 results)