2013 Fiscal Year Final Research Report
Beneficial effects of probiotics for obesity in children
| Project/Area Number |
22500773
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Tokyo Women's Medical University (2013)
Juntendo University (2010-2012) |
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Principal Investigator |
NAGATA Satoru 東京女子医科大学, 医学部, 教授 (70266055)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Toshiaki 順天堂大学, 医学部, 教授 (30260889)
OHTSUKA Yoshikazu 順天堂大学, 医学部, 准教授 (90338335)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 小児肥満 / プロバイオティクス / 腸内細菌叢 / 便中有機酸 / Lactobacillus casei シロタ株 / Bifidobacterium / 減量効果 / 脂質代謝 |
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| Research Abstract |
We performed this open study to clarify the usefulness of Lactobacillus casei strain Shirota (LcS)fermented milk in the reduction of body weight and prevention of metabolic syndrome in obese children. A significant reduction of the fecal bifidobacteria and acetic acid concentration were noted in the obese children compared with the controls prior to treatment. Continuous intake of LcS fermented milk for six months contributed to a reduction of body weight and decreased serum triglyceride levels, accompanied by a significant increase in the number of fecal bifidobacteria and an increased fecal acetic acid level in the obese group in comparison with those treated with kinesitherapy and dietetic treatment during the same period. LcS may help increase the proliferation of intestinal bifidobacteria, resulting in beneficial effects on the lipid metabolism, as evidenced by the increased fecal acetic acid, one of the main products of these bacteria, in obese children.
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[Journal Article] Effects of continuous intake of Lactobacillus casei strain Shirota-fermented milk containing on risk management of long-term inpatients at health service facilities for the elderly2011
Author(s)
Bian L, Nagata S, Asahara T, Rahman MS, Ohta T, Yuki N, Wang C, Takano K, Daibo M, Yamashiro Y, Nomoto K
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Journal Title
International Journal of Probiotics & Prebiotics
Volume: 6
Pages: 123-132
Peer Reviewed
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[Journal Article] Well-controlled proinflammatory cytokine responses of Peyer's patch cells to probiotic Lactobacillus casei2010
Author(s)
Chiba Y, Shida K, Nagata S, Wada M, Bian L, Wang C, Shimizu T, Yamashiro Y, Kiyoshima-Shibata J, Nanno M, Nomoto K
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Journal Title
Immunology
Volume: 130
Pages: 352-62
Peer Reviewed
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[Journal Article] Anti-infectious activity of synbiotics in a novel mouse model of Methicillin–Resistant Staphylococcus aureus infection2010
Author(s)
Lkhagvadorj E,Wada M, Bian L,Wang C, Chiba Y, Nagata S, Shimizu T, Yamashiro Y, Takahashi A, Asahara T, Nomoto K
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Journal Title
Microbiol Immunol
Volume: 54
Pages: 265-75
Peer Reviewed
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