2012 Fiscal Year Final Research Report
Investigation of food ingredients with anti-obese activity through inhibition of active ghrelin production
| Project/Area Number |
22500794
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OISO Shigeru 長崎国際大学, 薬学部, 准教授 (40513106)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 活性型グレリン / デスアシル型グレリン / オクタン酸 / グレリン安定発現株 |
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| Research Abstract |
Ghrelin is a gastric peptide hormone with orexigenic activity; therefore, inhibition of its production might prevent obesity. To identify candidate inhibitors of active ghrelin production, we established the AGS-GHRL8 cell line by transfection of ghrelin cDNA into AGS cells originating from human gastric carcinoma tissue. Heptanoic, oleic, and eicosapentaenoic acids inhibited active ghrelin secretion from AGS-GHRL8 cells, whereas acetic and butyric acids did not. Thus, oleic and eicosapentaenoic acids would be candidate food ingredients with anti-obese activity through inhibition of active ghrelin production.
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