2012 Fiscal Year Final Research Report
he search of the functional ingredient of the food having the regulatory activity of galectin -9 expression and the functional analysis
| Project/Area Number |
22500795
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Shokei University |
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Principal Investigator |
SAKATA Atsuko 尚絅大学, 生活科学部, 教授 (70167849)
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| Co-Investigator(Renkei-kenkyūsha) |
HIRASHIMA Mituomi 香川大学, 医学部, 教授 (70109700)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ガレクチン-9 / 免疫調節 |
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| Research Abstract |
Using U937 cells and human PBMC, we searched for the functional ingredient of the foodhaving the regulatory activity of galectin-9 expression which had particularly a varietyof immunoregulatory action in galectin family molecules. In the result, fucoidan, notlychee extract or catechin, had inhibitory activity of galectin-9 expression withstrong inflammatory cytokine induction, suggesting the possibility that fucoidan mightenhance the inflammatory cytokine production by reducing expression of galectin-9 whichhas an immunosuppressive function.
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