2012 Fiscal Year Final Research Report
Development of novel bioactive organo-medicinal compounds against metabolic syndrome
| Project/Area Number |
22550032
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Shizuoka University |
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Principal Investigator |
YODA Hidemi 静岡大学, 工学部, 教授 (20201072)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Masaki 静岡大学, 工学部, 准教授 (30313935)
SENGOKU Tetsuya 静岡大学, 工学部, 助教 (70451680)
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| Co-Investigator(Renkei-kenkyūsha) |
ASANO Naoki 北陸大学, 薬学部, 教授 (50121265)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 複素環 / アルカロイド / ポリヒドロキシ / 立体異性体 |
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| Research Abstract |
Recently a new series of hyacinthacines were isolated from bluebells and grape hyacinths by Asano et al. These compounds strongly inhibit various glycosidases in a reversible and competitive manner. While many total syntheses of hyacinthacine A series have been recently completed by several groups, the synthesis of hyacinthacine B and C series, however, has not been achieved to date. The central feature of this report is to describe the details of the first and expeditious route for the stereoselective construction of hyacinthacine B1, B2, C2, and C3 starting from (S)-2-pyrrolidone-5-carboxylic acid.
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