2012 Fiscal Year Final Research Report
Onset of endoreplication through the regulation of G2/M phase during the cell cycle
| Project/Area Number |
22570040
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plant molecular biology/Plant physiology
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| Research Institution | Nagoya University |
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Principal Investigator |
ITO Masaki 名古屋大学, 生命農学研究科, 准教授 (10242851)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞分裂 / 細胞周期 / エンドリプリケーション / 核内倍加 / 植物 / ユビキチンリガーゼ / 転写制御 |
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| Research Abstract |
Plant cells often increase their cellular DNA content (ploidy) during plant development, through the modified cell cycle where DNA replication occurs repeatedly without intervening cell division. Although it has been generally believed that increased cellular ploidy may be important for the control of cell size, metabolic activity, and cell differentiation, little is known about the regulatory mechanisms of this processes. In this study, we have focused on the two factors, GIG1 and SCL, that may have important roles in increasing cellular ploidy. We showed that GIG1 may negatively regulate ploidy increase by inhibiting a specific protein degradation system acing during G2 and mitosis. On the other hand, SCL may accelerate increasing ploidy by transcriptional repression of genes involved in DNA replication, possibly during M phase in the cell cycle.
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[Journal Article] Roles of GIG1 and UVI4 in genome duplication in Arabidopsis thaliana.2012
Author(s)
Iwata, E., Ikeda, S., Abe, N., Kobayashi, A., Kurata, M., Matsunaga, S., Yoshioka, Y., Criqui, M.-C., Genschik, P., Ito, M.
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Journal Title
Plant Signal. Behav.
Volume: 7
Pages: 1079 -1081
DOI
Peer Reviewed
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[Journal Article] GIGAS CELL1, a novel negative regulator of the anaphase-promoting complex/cyclosome, is required for proper mitotic progression and cell fate determination in Arabidopsis.2011
Author(s)
Iwata, E., Ikeda, S., Matsunaga, S., Kurata, M., Yoshioka, Y., Criqui, M-C, Genschik, P., Ito, M
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Journal Title
Plant Cell
Volume: 23
Pages: 4382-4393
DOI
Peer Reviewed
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[Journal Article] Mutations in MYB3R1 and MYB3R4 cause pleiotropic developmental defects and preferential down-regulation of multiple G2/M-specific genes in Arabidopsis thaliana.2011
Author(s)
Haga, N., Kobayashi, K., Suzuki, T., Maeo, K., Kubo, M., Ohtani, M., Mitsuda, N., Demura, T., Nakamura, K., Jurgens, G., Ito, M.
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Journal Title
Plant Physiol
Volume: 157
Pages: 706-717
DOI
Peer Reviewed
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