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2012 Fiscal Year Final Research Report

Roles of heparan sulfate glycosaminoglycan containing positive charged domain on cell proliferation, differentiation and apoptosis

Research Project

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Project/Area Number 22570150
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional biochemistry
Research InstitutionNihon Pharmaceutical University (2011-2012)
Aichi Cancer Center Research Institute (2010)

Principal Investigator

KYOGASHIMA Mamoru  日本薬科大学, 薬学部, 教授 (50225091)

Co-Investigator(Renkei-kenkyūsha) EHARA Takashi  松本大学, 人間健康学部, 教授 (00203646)
ODA Koji  愛知県がんセンター(研究所), 疫学・予防部, 研究員 (30311715)
Project Period (FY) 2010 – 2012
Keywords糖鎖生物学 / ヘパラン硫酸糖鎖 / 陽性荷電
Research Abstract

Expression of heparan sulfate glycosaminoglycan with positively charged domain (JM403 antigen) in cytoplasm was examined in proliferative and/or differentiated cells of cancers and fetal rodent tissues. The JM403 antigen was limitedly expressed in epithelial cells but not in nervous cells and connective tissue cells, suggesting its involvement with epithelial proliferation and differentiation.

  • Research Products

    (4 results)

All 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Cytoplasmic expression of the JM403 antigen GlcA-GlcNH3+ on heparan sulfate glycosaminoglycan in mammary carcinomas - A novel proliferative biomarker for breast cancers with high malignancy2010

    • Author(s)
      Fujii M, Yusa A, Yokoyama Y, Kokuryo T, Tsunoda N, Oda K, Nagino M, Ishimaru T, Shimoyama Y, Utsunomiya H, Iwata H, Itoh Y, Itoh J, Kannagi R, Kyogashima M
    • Journal Title

      Glycoconj J

      Volume: 27 Pages: 661-672

    • DOI

      doi:10.1007/s10719-010-9311-4

    • Peer Reviewed
  • [Presentation] JM403 antigen GlcA-GlcNH3+on heparan sulfate glycosaminoglycan may be involved in cell proliferation and apoptosis2011

    • Author(s)
      Akiko Yusa, Masahiro Fujii, Hirotoshi Utsunomiya, Kouji Tanaka, Reiji Kannagi, Koji Oda, Mamoru Kyogashima
    • Organizer
      XXI International Symposium on Glycoconjugates
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2011-08-22
  • [Presentation] 陽性荷電をもつヘパラン硫酸糖 鎖GlcA-GlcNH3+の細胞生物学的研究2010

    • Author(s)
      遊佐亜希子、藤井正宏、後藤嘉子、小田高司、宇都宮洋才、京ケ島 守、神奈木玲児
    • Organizer
      糖鎖科学名古屋拠点「若手の力」フォーラム第8回
    • Place of Presentation
      名古屋
    • Year and Date
      2010-09-06
  • [Presentation] Different expression of cationic heparan sulfate in the cells at proliferation2010

    • Author(s)
      Akiko Yusa, Masahiro Fujii, Yoshiko Goto, Koji Oda, Hirotoshi Utsunomiya, Mamoru Kyogashima, Reiji Kannagi
    • Organizer
      differentiation and apoptosis.BMB2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-01-20

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Published: 2014-08-29  

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