2012 Fiscal Year Final Research Report
The function of lysine-methylated PCAF molecule
| Project/Area Number |
22570172
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Kyushu University |
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Principal Investigator |
YAMAMOTO Ken 九州大学, 生体防御医学研究所, 准教授 (60274528)
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| Co-Investigator(Kenkyū-buntansha) |
TAHIRA Tomoko 九州大学, 生体防御医学研究所, 講師 (50155230)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 遺伝子転写 / PCAF / リジンメチル化 |
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| Research Abstract |
There exist several methyltransferases targeting histone molecules (HMTase). We previously reported that one of HMTase, Set9, methylates multiple lysine residues of p300/CBP-associated factor (PCAF). To elucidate biological relevance of this PCAF methylation, we examined functional change of PCAF cased by methylation. We found that lysine methylation did not alter stability and self-acethylation of PCAF; however, its acethylation activity to P53 and histone H3 molecules was impaired by this modification. Our results implicate a novel transcription pathway including Set9 and PCAF via multiple lysine methylation.
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[Journal Article] P300/CBP-associated factor regulates Y-box binding protein-1 expression and promotes cancer cell growth, cancer invasion and drug resistance2010
Author(s)
Shiota M, Yokomizo A, Tada Y, Uchiumi T, Inokuchi J, Tatsugami K, Kuroiwa K,Yamamoto K, Seki N, Naito S
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Journal Title
Cancer Sci
Volume: 101
Pages: 1797-1806
DOI
Peer Reviewed
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