2012 Fiscal Year Final Research Report
Analysis of a novel signaling pathway which links G0 to M phases via centrosomal kinases
| Project/Area Number |
22570185
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NOJIMA Hiroshi 大阪大学, 微生物病研究, 教授 (30156195)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 中心体 / キナーゼ / M 期 / Lats / Aurora / Hippo / リン酸化 / G0 期 |
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| Research Abstract |
Chromosomal instability (CIN) that is one of the essential properties of tumor malignancy is associated with abnormal centrosome amplification and disturbed mitotic (M phase) checkpoint control, suggesting that certain centrosomal kinases cause induction of CIN. Furthermore, abnormal cell growth due to inability to enter the G0 phase is another important trait of cancer. In this study, we demonstrate that the centrosomal kinases, Lats1 and Lats2, control the mitotic checkpoint through centrosomal integrity and chromosomal segregation and prevent abnormal cell growth. These results suggest that Lats1/2 kinases comprise a novel signaling pathway which links G0 to M phases of the cell cycle.
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[Journal Article] Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury.2013
Author(s)
Del Re DP, Yang Y, Nakano N, Cho J, Zhai P, Yamamoto T, Zhang N, Yabuta N, Nojima H, Pan D, Sadoshima J
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Journal Title
J Biol Chem
Volume: 288
Pages: 3977-88
DOI
Peer Reviewed
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[Journal Article] N-terminal truncation of Lats1 causes abnormal cell growth control and chromosomal instabilitya H2013
Author(s)
Yabuta N, Mukai S, Okamoto A, Okuzaki D, Suzuki H, Torigata K, Yoshida K, Okada N, Miura D, Ito A, Ikawa M, Okabe M, Nojima H
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Journal Title
J Cell Sci
Volume: 126
Pages: 508-20
DOI
Peer Reviewed
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[Journal Article] Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice2012
Author(s)
Nishio M, Hamada K, Kawahara K, Sasaki M, Noguchi F, Chiba S, Mizuno K, Suzuki SO, Dong Y, Tokuda M, Morikawa T, Hikasa H, Eggenschwiler J, Yabuta N, Nojima H, Nakagawa K, Hata Y, Nishina H, Mimori K, Mori M, Sasaki T, Mak TW, Nakano T, Itami S, Suzuki
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Journal Title
J Clin Invest.
Volume: 122
Pages: 4505-18
DOI
Peer Reviewed
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