2012 Fiscal Year Final Research Report
Mechanism of the reorganization of developmental gene regulatory network
| Project/Area Number |
22570198
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Tohoku University |
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Principal Investigator |
MINOKAWA Takuya 東北大学, 大学院・生命科学研究科, 准教授 (60400305)
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| Research Collaborator |
YAMAZAKI Atsuko 東北大学, 大学院・生命科学研究科, 日本学術振興会特別研究員(PD)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 進化発生 |
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| Research Abstract |
The purpose of the present research is to elucidate the molecular mechanism responsible for the gene regulatory network (GRN) reorganization during animal evolution. Various species belonging to the ambulacraria have been used as model species. Especially, we are interested in tbr expression in the apical organ of the sand dollar Peronella japonica. We confirmed that P. japonica is an exceptional echinoid species that possesses tbr expression in the apical organ. The cis-regulatory analysis for P. japonica tbr revealed that approximately 1 kb upstream sequence of the coding region suffices to activate transcription of a reporter gene in the broad regions containing mesoderm and ectoderm.
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