2012 Fiscal Year Final Research Report
Mechanisms of the growth inhibition in social defeat model of rats
| Project/Area Number |
22580303
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | Ibaraki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
CHONAN Shigeru 茨城大学, 農学部, 准教授 (70312775)
KOHARI Daisuke 茨城大学, 農学部, 准教授 (50396595)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 畜産学 / ストレス / マロニル-CoA / うつ病 / 視床下部 / 成長 / 神経科学 / 栄養学 |
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| Research Abstract |
This research focused on the growth inhibition in social defeated model of rats using the resident-intruder paradigm. The defeated model of rats showed anorexia-like symptoms following growth inhibition. Possibly, this was based on the disruption of hypothalamic regulation for feeding behaviors including malonyl-CoA signal pathway, because malonyl-CoA level in the hypothalamus of defeated rats abnormally increased.
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