2012 Fiscal Year Final Research Report
Role of neutrophil mediated inflammatory reactions in the development of bovine dry-period mastitis caused by Staphylococcus aureus intramammary infection
| Project/Area Number |
22580347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | National Agriculture and Food Research Organization |
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Principal Investigator |
WATANABE Atsushi 独立行政法人農業・食品産業技術総合研究機構, 動物衛生研究所, 主任研究員 (60442810)
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| Co-Investigator(Kenkyū-buntansha) |
HATA Eiji 独立行政法人農業・食品産業技術総合研究機構, 動物衛生研究所, 主任研究員 (50355153)
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| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Kazuhiro 北海道大学, 大学院・獣医学研究科, 教授 (30192561)
HIRAI Tsunao 地方独立行政法人北海道立総合研究機構, 畜産試験場, 研究主幹 (80390855)
KIMURA Takashi 北海道大学, 人獣共通感染症リサーチセン ター, 准教授 (90261338)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 乳牛 / 乳房炎 / 黄色ブドウ球菌 / 好中球 / インターロイキン-8 / エラスターゼ / ラクトフェリン由来ペプチド |
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| Research Abstract |
The dry period bovine mastitis caused by Staphylococcus aureus infection shows characteristic pathogenesis that is lastingly developed. We showed that interleukin-8 (IL-8), leukocyte elastase, and inflammatory lactoferrin-derived peptides were released, in relation with the pathogenesis of S. aureus dry period mastitis, in mastitic mammary secretions. In the chronic stage of the mastitis, transforming growth factor-β2 that suppresses IL-8 secretion was suggested to be involved in subsiding of the inflammation.
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[Journal Article] Single intramammary infusion of recombinant bovine interleukin-8 at dry-off induces the prolonged secretion of leukocyte elastase, inflammatorylactoferrin-derived peptides, and interleukin-8 in dairy cows2012
Author(s)
Watanabe, A., Hirota, J., Shimizu, S., Inumaru, S. and Kimura, K
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Journal Title
Vet. Med. Int
Volume: 2012巻
Peer Reviewed
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[Presentation] Possible involvement of transforming growth factor-beta2 in the development of bovine dry period mastitis induced by intramammary infusion of Staphylococcus aureus2013
Author(s)
Watanabe, A., Hata, E., Hirota, J., Shimizu, S., Kadota, K, Slama, P., Chikayama, Y., Ishikawa, Y. and Kimura, K
Organizer
31st World Veterinary Congress
Place of Presentation
プラハ, チェコ
Year and Date
20130917-20
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[Presentation] Production of bovine transforming growth factor beta 1 following stimulation with lipopolysaccharide2012
Author(s)
Slama, P. , Zbysek, S., Slamova, R., Pavlik, A., Zdenek, H., Jiri, S. and Watanabe, A
Organizer
22nd IUBMB & 37th FEBS Congress
Place of Presentation
セビリア,スペイン
Year and Date
20120904-09
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[Presentation] CXCL8-induced mastitis during drying-off period in dairy cows: sustained secretions of CXCL8, leukocyte elastase andlactoferrin-derived peptides in mammary secretions2012
Author(s)
Watanabe, A., Hirota, J., Shimizu, S. , Inumaru, S and Kimura, K
Organizer
XXVII World Buiatrics Congress2012
Place of Presentation
リスボン, ポル トガル
Year and Date
2012-06-04
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[Presentation] Cytotoxicity of the staphylococcal leukocidins on bovine cells2011
Author(s)
Hata, E., Watanabe, A., Uchida, I.,Tanaka, K., Tamamura, Y. and Takamatsu, D
Organizer
International Union of Microbiological Societies 2011(IUMS2011)
Place of Presentation
札幌市
Year and Date
2011-09-07
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