2012 Fiscal Year Final Research Report
Cellular and Immune Responses of Dairy Cows Induced by Intramammary Infusion of Lactic Acid Bacteria and Therapeutic Trials to Quarters of Cows with Mastitis.
| Project/Area Number |
22580354
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Rakuno Gakuen University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIGUCHI Hidetoshi 酪農学園大学, 獣医学群, 准教授 (00305905)
TANJI Yasunori 東京工業大学, 生命理工学研究科, 准教授 (00282848)
INANAMI Osamu 北海道大学, 獣医学研究科, 教授 (10193559)
SONOMOTO Kenji 九州大学, 農学研究院, 教授 (10154717)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 乳房炎 / 有用微生物 / 白血球機能修飾 / サイトカイン / 乳腺感染制御 |
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| Research Abstract |
The aim of this study was to characterize the cellular and immune responses of mammary gland by intramammary infusion (IMI) of Lactic acid bacteria (LAB) in cows, and to evaluate the therapeutic effects of IMI of LAB to lactating cows withmastitis. Marked increase of SCC were found in infused quarter at 24-48 hr post infusion. Significantly increased concentrations of immunoglobulins, anti-bacterial proteins and mRNA expression of cytokines on milk leukocytes were found in cows. In therapeutic trials, IMI of LAB to quarters leads to a marked cellular and immune responses in mammary gland. The IMI of LAB may have a possible rolefor control of mastitis.(key words:lactic acid bacteria, mammary gland defense, immune-therapeutic trial, bovine mastitis control)
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[Journal Article] Effectiveness of slightly acidic electrolyzed water for improvement of hygienic conditions of teat liners of automatic milking system2012
Author(s)
Nagahata, H., Yuge, K., Moriyama, A., Takahashi, A., Iwano, H., Higuchi, H., Mitamura, T. & Matsuyama, H
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Journal Title
Milchwissenschaft
Volume: 67(2): 123-126
Peer Reviewed
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[Journal Article] Analysis of cellular and immune responses of dairy cows induced by intramammary infusion of lactic acid bacteria and therapeutic trials to quarters of cows with mastitis2012
Author(s)
Nagahata, H., Moriyama, A., Koshi, A.,Mukai, T., Natsume, Y., Higuchi, T., Koike, N. & Ando, T
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Journal Title
World Buiatrics Congress
Pages: 32-33
Peer Reviewed
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[Journal Article] Altered leukocyte responsiveness in dairy cows with naturally occurring chronic Staphylococcus aureus mastitis2011
Author(s)
Nagahata, H., Kawai, H., Higuchi, H., Kawai, K., Yayou, K. & Chang, C. J
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Journal Title
J. Vet. Med. Sci
Volume: 73(7): 885-894
Peer Reviewed
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[Journal Article] Changes in acute-phase proteins and cytokines in serum and milk whey from dairy cows with naturally occurring peracute mastitis caused by Klebsiella pneumonia and the relationship to clinical outcome2011
Author(s)
Hisaeda, K., Arima, H., Sonobe, T., Nasu, M., Hagiwara, K., Kirisawa, R., Takahashi, T., Kikuchi, N. & Nagahata, H
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Journal Title
J. Vet. Med. Sci
Volume: 73(11): 1399-1404
Peer Reviewed
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[Presentation] Analysis of cellular and immune responses of dairy cows induced by intramammary infusion of lactic acid bacteria and therapeutic trials to quarters of cows with mastitis2012
Author(s)
Nagahata, H., Moriyama, A., Koshi, A., Mukai, T., Natsume, Y., Higuchi, T., Koike, N. & Ando, T
Organizer
World Buiatrics Congress
Place of Presentation
Lisbon, Portugal
Year and Date
2012-06-06
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[Presentation] Characterization of novel Staphylococcus aureus bacteriophages with wide host ranges and their potential as therapeutic agents for bovine mastitis2012
Author(s)
Iwano, H., Higuchi, H., Inoue, H., Kobayashi, H., Nagahata, H., Yokota, H. & Tanji, Y
Organizer
World Buiatrics Congress
Place of Presentation
Lisbon, Portugal
Year and Date
2012-06-06
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