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2012 Fiscal Year Final Research Report

Novel pathological mechanisms and therapy strategy for canine and feline kidney diseases: association with COX and RA

Research Project

  • PDF
Project/Area Number 22580364
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical veterinary science
Research InstitutionKagoshima University

Principal Investigator

YABUKI Akira  鹿児島大学, 共同獣医学部, 准教授 (10315400)

Co-Investigator(Renkei-kenkyūsha) YAMATO Osamu  鹿児島大学, 共同獣医学部, 教授 (80261337)
ICHII Osamu  北海道大学, 獣医学部, 助教 (60547769)
HOSAKA Yoshinao  鳥取大学, 農学部, 准教授 (00337023)
Research Collaborator MIZUKAMI Keijiro  鹿児島大学, 共同獣医学部, 大学院生
MITANI Sawane  鹿児島大学, 共同獣医学部, 大学院生
TOMINAGA Naomi  鹿児島大学, 共同獣医学部, 学部学生
Project Period (FY) 2010 – 2012
Keywords腎疾患 / シクロオキシゲナーゼ / レニン・アンジオテンシン系 / 犬 / 猫
Research Abstract

In the present study, we investigated pathological mechanisms of kidney diseases in dogs and cats, especially involvement of cyclooxygenase (COX) and renin-angiotensin (RA) system. Results from pathological investigation demonstrated close and complicated relationships between renal COX and RA system and progression of the kidney diseases, and such mechanisms were clearly differentbetween dogs and cats. Investigation using model mice demonstrated the renoprotective effect of piroxicam (COX inhibitor), and it was suggested that such renoprotective effect was induced from the downregulation of TGF-beta.

  • Research Products

    (6 results)

All 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Association between the intrarenal renin-angiotensin system and renal injury in chronic kidney disease of dogs and cats2013

    • Author(s)
      Mitani S, Yabuki A, Taniguchi K, Yamato O
    • Journal Title

      J Vet Med Sci

      Volume: 75 Pages: 127-133

    • Peer Reviewed
  • [Journal Article] A comparative study of chronic kidney disease in dogs and cats2012

    • Author(s)
      Yabuki A, Mitani S, Sawa M, Mizukami K, Fujiki M, Yamato O
    • Journal Title

      induction of cyclooxygenases.Res Vet Sci

      Volume: 93 Pages: 892-897

    • Peer Reviewed
  • [Presentation] 片側尿管結紮マウスモデルにおけるシクロオキシゲナーゼ阻害剤投与の影響2012

    • Author(s)
      富永 なおみ・矢吹 映・大和 修
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      (盛岡)
    • Year and Date
      20120900
  • [Presentation] 糸球体腎炎と膵炎を併発した犬の 3 例.2012

    • Author(s)
      矢吹 映・宮 豊・宮 紀子・野添伸樹・大和 修
    • Organizer
      第5回日本獣医腎泌尿器学会 学術総会
    • Place of Presentation
      東京
    • Year and Date
      20120800
  • [Presentation] Cyclooxygenase induction in canine and feline kidney diseases: Immunohistochemical expression and relation with pathological changes2011

    • Author(s)
      Yabuki A, Mitani S, Mizukami K, Yamato O
    • Organizer
      WSAVA World Congress
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      20111000
  • [Presentation] Immunohistochemical analysis of renin and angiotensin II in the kidneys of dogs and cats with kidney diseases2011

    • Author(s)
      Mitani S, Yabuki A, Mizukami K, Yamato O
    • Organizer
      WSAVA World Congress
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      20111000

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Published: 2014-08-29   Modified: 2015-10-15  

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