2012 Fiscal Year Final Research Report
Peroxisomal dysfunction and ER stress -A novel mechanism for the demyelination in central nervous system-
| Project/Area Number |
22590060
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
MORITA Masashi 富山大学, 大学院・医学薬学研究部(薬学), 准教授 (20191033)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ペルオキシソーム / ABCD1 / 小胞体ストレス / 自然免疫応答 / 副腎白質ジストロフィー |
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| Research Abstract |
The purpose of this project was to evaluate the relationship peroxisomal dysfunction anddemyelination. In this study, we focused on the ER stress and innate immunity in ABCD1-deficient primary astrocytes. Dysfunction of ABCD1, a peroxisomal membrane protein, caused a neurodegenerative disease called adrenoleukodystropy. We found that treatment of ligands for pattern recognition receptors induced the expression of cytokines and antiviral proteins in ABCD1-deficient astrocytes. These results suggest that dysfunction of ABCD1 lead to the disturbance of innate immune response, which result in the demyelination in adrenoleukodystrophy.
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[Journal Article] The structure of Physarum polycephalunhemaggulutinin I suggests a minimal carbohydrate recognition domain of legume lectin fold2011
Author(s)
Kouno T., Watanabe N., Sakai N., Nakamura T., Nabeshima Y., Morita M., Mizuguchi M., Aizawa T., Demura M., Imanaka T., Tanaka I, and Kawano K
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Journal Title
J. Mol. Biol
Volume: 405
Pages: 4083-4093
DOI
Peer Reviewed
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[Presentation] Establishment of screening system to discover candidates of chemical Chaperone that stabilize mutant ABCD1 responsible for adrenoleukodystrophy.2012
Author(s)
Kostsin, D. G., Lee, A., Yamazaki, K., Kawaguchi, K., Morita, M., and Imanaka, T
Organizer
The 4th EMBO Meeting
Place of Presentation
Nice, France
Year and Date
20120922-25
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[Presentation] ペルオキシソーム病の繊維芽細胞で検出される極長鎖脂肪酸含有脂質の分子構造決定2011
Author(s)
西澤千穂,永井徹,池田和貴,守田雅志,唐沢健,原田史子,佐藤典子,中西広樹,田口良,下澤伸行,今中常雄,井上圭三,横山和明
Organizer
日本薬学会第131年会
Place of Presentation
静岡
Year and Date
20110328-31
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[Presentation] ペルオキシソーム病の繊維芽細胞にみられる極長鎖脂肪酸含有脂質の分子構造決定2010
Author(s)
西澤千穂,永井徹,池田和貴,守田雅志,唐澤健,原田史子,佐藤典子,中西広樹,田口良,下澤伸行,今中常雄,井上圭三,横山和明
Organizer
第83回日本生化学会大会・第33回日本分子生物学会年会合同大会
Place of Presentation
神戸
Year and Date
20101207-12
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[Presentation] ペルオキシソーム病の繊維芽細胞に蓄積する極長鎖脂肪酸含有脂質2010
Author(s)
横山和明,西澤千穂,池田和貴,永井徹,守田雅志,原田史子,佐藤典子,唐沢健,今中常雄,下澤伸行,田口良
Organizer
第52回日本脂質生化学会
Place of Presentation
渋川
Year and Date
20100714-15
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