2012 Fiscal Year Final Research Report
Molecular mechanism of neuroprotection by molecular
| Project/Area Number |
22590084
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
NODA Mami 九州大学, 薬学研究院, 准教授 (80127985)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 酸化ストレス / 神経保護 / パーキンソン病 |
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| Research Abstract |
We showed that low concentration of molecular hydrogen (0.008 ppm) in drinkingwater had neuroprotective effects in Parkinson’s Disease model mice (Fujita et al., 2009). However, not only acute anti-oxidative effect but also upregulation of chaperone, heat shock protein (Hsp) 72, and involvement of gastric hormone, ghrelin, was suggested. These results will contribute to a preventive medicine which may be inducedby drinking hydrogen water.
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Research Products
(21 results)
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[Journal Article] A kavalactone derivative inhibits lipopolysaccharide-stimulated iNOS induction and NO production through activation of Nrf2 signaling in BV2 microglial cells2013
Author(s)
Terazawa R, Akimoto N, Kat o T, I t o h T, Fujita Y, Hamada N, Deguchi T, Iinuma M, Noda M, Nozawa Y, Ito M
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Journal Title
Pharmacol Res
Volume: 71
Pages: 34-43
DOI
Peer Reviewed
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[Journal Article] IL-6 Receptor Is a Possible Target against Growth ofMetastasized Lung Tumor Cells in the Brain2012
Author(s)
Noda M, Yamakawa Y, Matsunaga N, Naoe S, Jodoi T, Yamafuji M, AkimotoNoda M, Yamakawa Y, Matsunaga N, Naoe S, Jodoi T, Yamafuji M, Akimoto
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Journal Title
Int J Mol Sci
Volume: 14(1)
Pages: 515-26
DOI
Peer Reviewed
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