2012 Fiscal Year Final Research Report
Epilepsy research focusing on the potassium buffering function of brain astrocytes
| Project/Area Number |
22590092
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Osaka University of Pharmaceutical Sciences |
|---|
Principal Investigator |
OHNO Yukihiro 大阪薬科大学, 薬学部, 教授 (00432534)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 薬理学 |
|---|
| Research Abstract |
We focused on the potassium buffering function of brain astrocytes andanalyzed the pathophysiological changes in expression of the inwardly-rectifying potassium channel 4.1(Kir4.1), which mediates spatial potassium buffering in astrocytes, using various animal models ofepilepsy. Our results revealed that reduced expression (down-regulation) of astrocytic Kir4.1 channels inthe limbic system (e.g., amygdala and piriform cortex) is closely linked to induction of generalizedtonic-clonic seizures. In addition, studies using kindling models suggest that Kir4.1 channels negativelyregulate the epileptogenesis (i.e., induction and development of epileptic seizures). Thus, the presentstudy illustrates that astrocytic Kir4.1 channels would serve as a novel therapeutic target for epilepsy.
|
Research Products
(42 results)
-
-
[Journal Article] Expressionalanalysis of inwardly rectifying Kir4.1 channels inNoda epileptic rat (NER)2013
Author(s)
Yuya Harada, Yuki Nagao, Saki Shimizu,Tadao Serikawa, Ryo Terada, Megumi Fujimoto,Aoi Okuda, Takahiro Mukai, Masashi Sasa,Yoshihisa Kurachi, Yukihiro Ohno
-
Journal Title
Brain Res
Volume: 1517
Pages: 141-149
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
[Presentation] Pathophysiological alterations ofsynaptic vesicle protein 2A (SV2A) in Groggy rat,a rat model of absence seizure2012
Author(s)
Takahiro Okumura 、 Shizuka Ishihara, RyoTerada, Chie Tomita, Ryosuke Kitaya, KentaroTokutome, Tomoya Tanaka, Saki Shimizu,Yoshiko Kawai, Tadao Serikawa, Masashi Sasa,Yukihiro Ohno
Organizer
第85回日本薬理学会年会
Place of Presentation
京都
Year and Date
20120614-16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
