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2012 Fiscal Year Final Research Report

Study on the roles of DEC1 and DEC2 in the rhythmic regulation of lipid metabolism.

Research Project

  • PDF
Project/Area Number 22590223
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionHiroshima University

Principal Investigator

NOSHIRO Mitsuhide  広島大学, 大学院・医歯薬保健学研究院, 准教授 (00144858)

Project Period (FY) 2010 – 2012
Keywords概日リズム / 時計遺伝子 / 脂質代謝 / 脂肪分化 / 核内受容体 / DEC1 / DEC2
Research Abstract

DEC1 and DEC2 are involved in various biological phenomena including clock systems, cell differentiation, and metabolism. I identified novel nuclear receptor response elements, ROR-response elements, in Dec1 and Dec2promoters. I also examined expression of Rorα Dec1, andDec2in differentiating 3T3-L1 adipocytes. The results suggested that RORαsuppresses adipogenicdifferentiation at a later stage of differentiation by RORE-mediated stimulation of Dec1and Dec2expression.

  • Research Products

    (17 results)

All 2012 2011 2010

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (7 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Regulation of basic helix-loop-helix transcription factors Dec1 and Dec2 by RORalpha and their roles in adipogenesis2012

    • Author(s)
      Ozaki, N., Noshiro, M., Kawamoto, T., Nakashima, A., (他6名)
    • Journal Title

      Genes Cells

      Volume: 17 Pages: 109-121

    • DOI

      DOI:10.1111/j.1365-2443.2011.01574.x

    • Peer Reviewed
  • [Journal Article] BHLH transcription factor DEC2 regulates pro-apoptotic factor Bim in human oral cancer HSC-3 cells2012

    • Author(s)
      Wu, Y., Sato, F., Kawamoto, T., Noshiro, M.
    • Journal Title

      Biomed Res

      Volume: 33 Pages: 75-82

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22572381

    • Peer Reviewed
  • [Journal Article] Identification of a new clock-related element EL-box involved in circadian regulation by BMAL1/CLOCK and HES12012

    • Author(s)
      Ueshima, T., Kawamoto, T., Noshiro, M.,(他5名)
    • Journal Title

      Gene

      Volume: 510 Pages: 118-25

    • DOI

      DOI:10.1016/j.gene.2012.08.022

    • Peer Reviewed
  • [Journal Article] Smad3 and Snail show circadian expression in human gingival fibroblasts, human mesenchymal stem cell, and in mouse liver2012

    • Author(s)
      Sato, F., Wu, Y., Noshiro, M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 419 Pages: 441-446

    • DOI

      DOI:10.1016/j.bbrc.2012.02.076

    • Peer Reviewed
  • [Journal Article] The basic helix-loop-helix transcription factor DEC2 inhibits TGF-beta-induced tumor progression in human pancreatic cancer BxPC-3 cells2012

    • Author(s)
      Sato, F., Kawamura, H., Kawamoto, T., Noshiro, M.,(他10名)
    • Journal Title

      Int J Mol Med

      Volume: 30 Pages: 495-501

    • DOI

      DOI:10.3892/ijmm.2012.1037

    • Peer Reviewed
  • [Journal Article] The BHLH transcription factor DEC1 plays an important role in the epithelial-mesenchymal transition of pancreatic cancer2012

    • Author(s)
      Wu, Y., Kawamoto, T., Noshiro, M., et al.(他10名)
    • Journal Title

      Int J Oncol

      Volume: 41 Pages: 1337-1346

    • DOI

      DOI:10.3892/ijo.2012.1559

    • Peer Reviewed
  • [Journal Article] Basic helix-loop-helix transcription factors DEC1 and DEC2 regulate the paclitaxel-induced apoptotic pathway of MCF-7 human breast cancer cells2011

    • Author(s)
      Wu, Y., Sato, F., Kawamoto, T., Fujimoto, K., Noshiro, M., (他4名)
    • Journal Title

      Int J Mol Med

      Volume: 27 Pages: 491-495

    • DOI

      DOI:10.3892/ijmm.2011.617

    • Peer Reviewed
  • [Journal Article] Anti-apoptotic effect of the basic helix-loop-helix (bHLH) transcription factor DEC2 in human breast cancer cells2010

    • Author(s)
      Liu, Y., Sato, F., Kawamoto, T., Noshiro, M.
    • Journal Title

      Genes Cells

      Volume: 15 Pages: 315-325

    • DOI

      DOI:10.1111/j.1365-2443.2010.01381.x

    • Peer Reviewed
  • [Presentation] 概日リズムを制御する新規時計エレメント EL-box の同定2012

    • Author(s)
      河本健、能城光秀、藤本勝巳、加藤幸夫
    • Organizer
      第54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      郡山
    • Year and Date
      20120914-16
  • [Presentation] DEC 研究の展望2012

    • Author(s)
      血圧制御など 加藤幸夫 シンポジウム
    • Organizer
      時刻と時間の生理学
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-10
  • [Presentation] 時計遺伝子 DEC1 の発現調節と機能における核内受容体との関連2012

    • Author(s)
      能城光秀
    • Organizer
      時刻と時間の生理学
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-10
  • [Presentation] 核内受容体 RORαによる時計遺伝子DEC1,DEC2 の発現調節と脂肪分化: 尾崎徳継2011

    • Author(s)
      能城光秀、河本健、福崎麗、藤本勝巳、丹根一夫、加藤幸夫
    • Organizer
      第52回日本生化学会中国・四国支部例会
    • Place of Presentation
      広島市
    • Year and Date
      20110513-14
  • [Presentation] 間葉系幹細胞の軟骨分化におけるDEC2の役割2011

    • Author(s)
      笹本智子、藤本勝巳、金輪真佐美、河本健、能城光秀、道田将彦、尾崎徳継、丹根一夫、加藤幸夫
    • Organizer
      第52回日本生化学会中国・四国支部例会
    • Place of Presentation
      広島市
    • Year and Date
      20110513-14
  • [Presentation] 核内受容体 (ROR・) と SREBP1c によるベーシック・ヘリックス・ループ・ヘリックス型転写因子(Dec1, Dec2) の発現調節と脂肪分化2010

    • Author(s)
      尾崎徳継,能城光秀,福崎麗, 河本健,藤本勝巳,丹根一夫,加藤幸夫
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会・合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      20101207-10
  • [Presentation] 核内受容体 (ROR・) による時計遺伝子 (Dec1, Dec2) の制御2010

    • Author(s)
      尾崎徳継、能城光秀、河本健、藤本勝巳、丹根一夫、加藤幸夫
    • Organizer
      第51回日本生化学会中国・四国支部例会
    • Place of Presentation
      山口市
    • Year and Date
      20100514-15
  • [Patent(Industrial Property Rights)] 脂質代謝関連疾患の検査方法、ならびに脂質代謝関連疾患の予防および/または治療剤の評価方法2011

    • Inventor(s)
      加藤幸夫、河本健、藤本勝巳、能城光秀
    • Industrial Property Rights Holder
      広島大学
    • Industrial Property Number
      特願 2011-22172 号
    • Filing Date
      2011-02-03
  • [Patent(Industrial Property Rights)] 非ヒト動物、細胞、血圧調節物質の評価方法、血圧調節条件の評価方法および血圧の調節方2010

    • Inventor(s)
      加藤幸夫、河本健、能城光秀、中島歩
    • Industrial Property Rights Holder
      広島大学
    • Industrial Property Number
      特願 2010-236891 号
    • Filing Date
      2010-10-21

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Published: 2014-08-29  

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