2013 Fiscal Year Final Research Report
Neuropeptidergic regulation of sociosexual behavior in rodents
| Project/Area Number |
22590229
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Teikyo University of Science & Technology (2011-2013)
Nippon Medical School (2010) |
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Principal Investigator |
KONDO Yasuhiko 帝京科学大学, 生命環境学部, 准教授 (00192584)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 視床下部室傍核 / 視索前野 / 扁桃体内側核 / 母性行動 / 嗅覚選好性 / 性行動 / オキシトシン / げっ歯類 |
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| Research Abstract |
The social behavior in rodents is regulated by the hypothalamus through sensory signals from chemosensory organs. In the hypothalamus, a neuropeptide, oxytocin, has been shown to mediate the regulation of social behavior. In this study, we examine sociosexual behavior in mice deficient for oxytocin gene (OTKO mice). Alternative choice test for conspecific odors revealed that OTKO mice showed a lack of preference for opposite-sex odor. In addition, OTKO deteriorated accept of male mouse in sexually naïve females, while OTKO did not affect male sexual behavior. We also tested for olfactory preference in female rats for pup odors. The experiment demonstrated that lower responsiveness to pup in virgin females than that of multiparous females was due to lower responsiveness of oxytocin neurons. Administration of oxytocin modified olfactory preference for pup in virgin females.
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