2012 Fiscal Year Final Research Report
A role of dbpA, DNA binding protein in Hodgkin lymphoma
| Project/Area Number |
22590338
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Juntendo University |
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Principal Investigator |
MOMOSE Shuji 順天堂大学, 医学部, 非常勤講師 (70360344)
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| Co-Investigator(Kenkyū-buntansha) |
TAMARU Jun-ichi 埼玉医科大学, 医学部, 教授 (30188429)
梶野 一徳 順天堂大学, 医学部, 助教 (80260066)
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| Project Period (FY) |
2010 – 2012
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| Keywords | CD30 / dbpA / リンパ腫 / 病理学 |
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| Research Abstract |
dbpA, DNA-binding protein A is belived to be involved in DNA recombination in E.Coli. We found dbpA is highly expressed in CD30 positive lymphocytes, which is restricted to activated lymphocyte in normal tissue. Also dbpA is highlyexpressed in CD30+lymphoma, classical Hodgkin lymphoma and anaplastic lymphoma. As it is well known that constitutive activation of NF・B signaling is a characteristic feature of Hodgkin lymphoma, dbpA seemed to act in a downstream molecule of NF・B signaling pathway.
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[Journal Article] Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter2010
Author(s)
Tan K, Kajino K, Momose S, Masaoka A, Sasahara K, Shiomi K, Izumi H, Abe M, Ohtsuji N, Wang T, Hino O, Fujii H
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Journal Title
Hum Pathol
Volume: 41(9)
Pages: 1330-8
Peer Reviewed
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