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2012 Fiscal Year Final Research Report

Mechanisms of radiation-related pediatric thyroid cancer

Research Project

  • PDF
Project/Area Number 22590344
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research Institution独立行政法人 国立病院機構 長崎医療センター・臨床研究センター (2012)
Department of Clinical Research, National Hospital Organization Nagasaki Medical Center (2010-2011)

Principal Investigator

ITOU Masahiro  独立行政法人 国立病院機構 長崎医療センター・臨床研究センター, 機能形態研究部, 部長 (30184691)

Co-Investigator(Kenkyū-buntansha) NAKASHIMA Masahiro  長崎大学, 医歯(薬)学総合研究科, 教授 (50284683)
Project Period (FY) 2010 – 2012
KeywordsChernobyl / Thyroid cancer / Papillary carcinoma / Childhood / Radiation / Iodine
Research Abstract

The Chernobyl Tissue Bank has contributed to data/tissue collection and 4,288 cases have been registered. The age at diagnosis and the latency period from exposure to radiation were correlated with tumor morphology and aggressiveness. Low levels of iodine intake seemed to influence the formation of morphology. Specific genetic mutation by radiation injury has not been identified at individual levels.

  • Research Products

    (16 results)

All 2013 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (9 results) Book (2 results)

  • [Journal Article] 放射線と甲状腺癌2013

    • Author(s)
      伊東 正博(加藤良平, 廣川満良(編))
    • Journal Title

      病理と臨床

      Volume: 31(1) Pages: 1-12

    • Peer Reviewed
  • [Journal Article] Long-term trend of thyroid cancer risk among Japanese atomic-bomb survivors: Sixty years after exposure.2013

    • Author(s)
      Furukawa K, Ito M
    • Journal Title

      Int J Cancer.

      Volume: 132(5) Pages: 1222-1226

    • Peer Reviewed
  • [Journal Article] The Chernobyl thyroid cancer experience: Pathology.2011

    • Author(s)
      LiVolsi V, Ito M
    • Journal Title

      Clin Oncol.

      Volume: 23(4) Pages: 261-267

    • Peer Reviewed
  • [Journal Article] Mutational and clinico-pathological analysis of papillary thyroid carcinoma in Serbia2011

    • Author(s)
      Stanojevic B, Nakashima M
    • Journal Title

      Endocr J.

      Volume: 58(5) Pages: 381-393

    • Peer Reviewed
  • [Journal Article] Dynamics of ionizing radiation-induced DNA damage response in reconstituted three-dimensional human skin tissue2010

    • Author(s)
      Suzuki K, Nakashima M
    • Journal Title

      Radiat Res.

      Volume: 174(4) Pages: 415-423

    • Peer Reviewed
  • [Presentation] ウクライナ成人の甲状腺乳頭癌の組織像は本邦症例とことなるのか?2012

    • Author(s)
      伊東正博,Bogdanova T, Saenko V,前田茂人,近藤久義,山下俊一
    • Organizer
      第55回日本甲状腺学会
    • Place of Presentation
      アクロス福岡
    • Year and Date
      20121129-1201
  • [Presentation] チェルノブイリ組織バンクの現状と新たな展開2012

    • Author(s)
      伊東正博, Tatiana Bogdanova, Alexander Abrosimov, Guido Fadda, Jeniffer Hunt, Gerry Thomas, Virginia LiVolsi, 中島正洋、山下俊一
    • Organizer
      第55回日本放射線影響学会
    • Place of Presentation
      仙台
    • Year and Date
      20120606-09
  • [Presentation] 成熟ラット甲状腺放射線発がん過程でのゲノム不安定性の関与2012

    • Author(s)
      蔵重智美, 松山睦美, 七條和子, 鈴木啓司, 成毛有紀, 伊東正博, 中島正洋
    • Organizer
      第100回日本病理学会
    • Place of Presentation
      横浜
    • Year and Date
      20120428-30
  • [Presentation] チェルノブイリの甲状腺癌2012

    • Author(s)
      伊東正博
    • Organizer
      第101回日本病理学会
    • Place of Presentation
      東京
    • Year and Date
      20120426-28
  • [Presentation] International Cooperation to Establish Post Chernobyl NIS Thyroid Tissue, Nucleic Acid and Data Banks2012

    • Author(s)
      Masahiro Ito
    • Organizer
      20th Pathology Panel Meeting
    • Place of Presentation
      Charing Cross Hospital, Imperial、London
    • Year and Date
      20120118-20
  • [Presentation] チェルノブイリ周辺の小児甲状腺癌の病理組織学的特徴2011

    • Author(s)
      伊東正博, Bogdanova T, Abrosimov A, Fadda G, Hunt J, Thomas G, LiVolsi V, 中島正洋、山下俊一
    • Organizer
      第54回日本甲状腺学会
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      20111122-23
  • [Presentation] Pathology review of childhood thyroid cancer around Chernobyl2011

    • Author(s)
      Ito M, Bogdanova T, Abrosimov A, Fadda G, Hunt J, LiVolsi V, Thomas G, Nakashima M, Yamashita S.
    • Organizer
      The 6th International Symposium of Nagasaki University Global COE Program "Global Strategic Center for Radiation Health Risk Control": A New Challenge of Radiation Health Risk Management
    • Place of Presentation
      Nagasaki
    • Year and Date
      20111020-22
  • [Presentation] Zurnadzhy L, Thomas G. Thyroid cancer pathology in Ukraine after the Chernobyl accident2011

    • Author(s)
      Bogdanova T, LiVolsi V, Williams ED, Ito M,
    • Organizer
      7th NCRI Cancer Conference
    • Place of Presentation
      CTB Symposium, Liverpool, UK
    • Year and Date
      2011-11-19
  • [Presentation] Immunofluorescence analysis of P53-binding protein 1 as a new molecular indicator for malignant potency and genomic instability in thyroid follicular neoplasms2010

    • Author(s)
      Mussazhanova Z,Nakashima M, Saenko V, Naryke Y, Suzuki K, Mitsutake N, Ito M, Nishihara E, Hirokawa M, Yamashita S.
    • Organizer
      第14回国際甲状腺学会
    • Place of Presentation
      パリ, フランス
    • Year and Date
      20100911-16
  • [Book] Pathology review of childhood thyroid cancer around Chernobyl. In Nakashima M, Takamura N, Suzuki K, Yamashita S (Eds). A new challenge of radiation health risk management2012

    • Author(s)
      Ito M, Bogdanova T, Nakashima M
    • Total Pages
      205-212
    • Publisher
      Nagasaki Newspaper Publish
  • [Book] II.放射線被曝と甲状腺癌:「腫瘍病理鑑別診断アトラス 8.甲状腺癌」 坂本穆彦,廣川満良(編)2011

    • Author(s)
      伊東 正博
    • Total Pages
      197-203
    • Publisher
      文光堂

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Published: 2014-08-29   Modified: 2015-11-04  

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