2012 Fiscal Year Final Research Report
Role of plasma ribosomal protein S19 in cellular immunity
| Project/Area Number |
22590348
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kumamoto University |
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Principal Investigator |
SEMBA Umeko 熊本大学, 大学院・生命科学研究部, 助教 (50109691)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Tetsuro 熊本大学, 大学院・生命科学研究部, 教授 (60112405)
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| Project Period (FY) |
2010 – 2012
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| Keywords | RP S19 / 補体系 / 結核菌 |
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| Research Abstract |
When mycobacterial dead cells were exposed to plasma, ribosomalprotein S19 (RP S19) was cross-linked by a transglutaminase-catalyzed reaction on themycobacterium membrane, working as the negatively charged scaffold, during bloodcoagulation. The cross-linked RP S19 dimer induced chemotactic response ofmonocytes/macrophages recruitment via C5a receptor, suggesting phagocytosis ofmycobacterium by recruited macrophages. C5a anaphylatoxin was partly involved in thismonocyte chemotaxis. It was demonstrated that RP S19 participated in innate immunityagainst the mycobacterium infection in association with C5a.
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