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2013 Fiscal Year Final Research Report

Carbamate pesticide-induced immunotoxicity and its mechanism

Research Project

  • PDF
Project/Area Number 22590554
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionNippon Medical School

Principal Investigator

LI Qing  日本医科大学, 医学部, 准教授 (50250048)

Co-Investigator(Kenkyū-buntansha) KAWADA Tomoyuki  日本医科大学, 大学院医学研究科, 教授 (00224791)
Project Period (FY) 2010-04-01 – 2014-03-31
Keywords環境毒性学 / 免疫毒性学 / 農薬中毒 / アポトーシス / 抗癌タンパク / NK活性 / CTL活性 / LAK活性
Research Abstract

Carbamate pesticides are widely used throughout the world in agriculture as fungicides and insecticides. Since carbamate pesticides contribute to chemical sensitivity and allergy related diseases; therefore, it is very important to investigate the immunotoxicity of carbamate pesticides and its mechanism in the perspecive of preventive medicine. In this study, we found that ziram, a carbamate fungicide, significantly inhibits natural killer (NK), lymphokine-activated killer (LAK) and cytotoxic T lymphocyte (CTL) activities. We have also found that ziram significantly induced apoptosis and necrosis in NK and T cells, and reduced the intracellular levels of anticancer proteins in NK cells, which contributed to the inhibitions of NK, LAK and CTL activities.

  • Research Products

    (29 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (16 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Carbamate pesticide-induced apoptosis and necrosis in human natural killer cells2014

    • Author(s)
      Li Q, Kobayashi M, Kawada T
    • Journal Title

      J Biol Regul Homeost Agents

      Volume: 28 Pages: 23-32

    • Peer Reviewed
  • [Journal Article] Effect of ziram on natural killer, lymphokine-activated killer and cytotoxic T lymphocyte activity2012

    • Author(s)
      Li Q, Kobayashi M, Kawada T
    • Journal Title

      Arch Toxicol

      Volume: 86 Pages: 475-81

    • DOI

      10.1007/s00204-011-0771-5

    • Peer Reviewed
  • [Journal Article] Mechanism of ziram-induced apoptosis in human T lymphocytes2012

    • Author(s)
      Li Q, Kobayashi M, Kawada T
    • Journal Title

      Arch Toxicol

      Volume: 86(4) Pages: 615-23

    • DOI

      10.1007/s00204-011-0791-1

    • Peer Reviewed
  • [Journal Article] Mechanism of ziram-induced apoptosis in human natural killer cells2012

    • Author(s)
      Li Q, Kobayashi M, Kawada T
    • Journal Title

      Int J Immunopathol Pharmacol

      Volume: 25 Pages: 883-91

    • Peer Reviewed
  • [Journal Article] 亜慢性ETBE吸入ばく露によるマウス脾臓細胞への影響2012

    • Author(s)
      李卿,川田智之
    • Journal Title

      労働安全衛生総合研究所特別研究報告

      Volume: No.42 Pages: 163-170

    • Peer Reviewed
  • [Journal Article] Ziram induces apoptosis and necrosis in human immune cells2011

    • Author(s)
      Li Q, Kobayashi M, Kawada T
    • Journal Title

      Arch Toxicol

      Volume: 85 Pages: 355-61

    • DOI

      10.1007/s00204-010-0586-9

    • Peer Reviewed
  • [Journal Article] Effect of oral exposure to fenitrothion and 3-methyl-4-nitrophenol on splenic cell populations and histopathological alterations in spleen in Wistar rats2011

    • Author(s)
      Li Q, Kawada T
    • Journal Title

      Hum Exp Toxicol

      Volume: 30 Pages: 665-74

    • Peer Reviewed
  • [Journal Article] Effects of subchronic inhalation exposure to ethyl tertiary butyl ether on splenocytes in mice2011

    • Author(s)
      Li Q, Kobayashi M, Inagaki H, Hirata Y, Kawada T, Suda M, Wang RS
    • Journal Title

      Int J Immunopathol Pharmacol

      Volume: 24(4) Pages: 837-47

    • Peer Reviewed
  • [Journal Article] 環境因子が生体の免疫機構に及ぼす影響-プラス影響とマイナス影響の視点から-2011

    • Author(s)
      李卿、川田智之
    • Journal Title

      職業・環境アレルギー誌

      Volume: 18 Pages: 35-47

    • Peer Reviewed
  • [Presentation] Carbamate pesticides induce apoptosis in human T cells2013

    • Author(s)
      Li Q, Kobayashi M and Kawada T
    • Organizer
      49th Congress of the European Societies of Toxicology
    • Place of Presentation
      Interlaken, Switzerland
    • Year and Date
      20130901-04
  • [Presentation] カーバメイト系農薬によるヒトT細胞死とその機序2013

    • Author(s)
      李卿、小林麻衣子、川田智之
    • Organizer
      第86回日本産業衛生学会総会
    • Place of Presentation
      松山
    • Year and Date
      20130500
  • [Presentation] Carbamate pesticides induce apoptosis in human NK-92CI cells2013

    • Author(s)
      Li Q, Kobayashi M and Kawada T
    • Organizer
      52nd annual meeting of SOT (Society of Toxicology)
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      20130310-14
  • [Presentation] カーバメイト系農薬によるヒトNK細胞のアポトーシス2013

    • Author(s)
      李卿、小林麻衣子、川田智之
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢
    • Year and Date
      20130300
  • [Presentation] ヒト末梢血リンパ球内のperforin、granzymes及びgranulysinレベルがNK活性を予測できるのか?2012

    • Author(s)
      李卿、川田智之
    • Organizer
      第19回日本免疫毒性学会
    • Place of Presentation
      東京
    • Year and Date
      20120900
  • [Presentation] Ziram induces apoptosis in human natural killer cells2012

    • Author(s)
      Li Q, Kobayashi M and Kawada T
    • Organizer
      48th Congress of the European Societies of Toxicology
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      20120617-20
  • [Presentation] カーバメイト系農薬ZiramによるT細胞、単球系細胞及びNK細胞死の違い2012

    • Author(s)
      李卿、小林麻衣子、川田智之
    • Organizer
      第85回日本産業衛生学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      20120500
  • [Presentation] Effect of ziram on natural killer, lymphokine-activated killer and cytotoxic T lymphocyte activity2012

    • Author(s)
      Li Q, Kobayashi M and Kawada T
    • Organizer
      51st annual meeting of SOT
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      20120311-15
  • [Presentation] カーバメイト系農薬ZiramによるヒトNK細胞のアポトーシス2012

    • Author(s)
      李卿、小林麻衣子、川田智之
    • Organizer
      第82回日本衛生学会学術総会
    • Place of Presentation
      京都
    • Year and Date
      20120300
  • [Presentation] 農薬ZiramによるヒトTリンパ球アポトーシスのメカニズム2011

    • Author(s)
      李卿、小林麻衣子、川田智之
    • Organizer
      第18回日本免疫毒性学会
    • Place of Presentation
      千葉
    • Year and Date
      20110900
  • [Presentation] Ziram induces apoptosis in human T lymphocytes2011

    • Author(s)
      Li Q, Kobayashi M and Kawada T
    • Organizer
      47th Congress of the European Societies of Toxicology
    • Place of Presentation
      Paris, France
    • Year and Date
      20110828-31
  • [Presentation] カーバメイト系農薬によるNK、CTL及びLAK活性への影響2011

    • Author(s)
      李卿、小林麻衣子、川田智之
    • Organizer
      第84回日本産業衛生学会総会
    • Place of Presentation
      東京
    • Year and Date
      20110500
  • [Presentation] Ziram induces apoptosis in human immune cells2011

    • Author(s)
      Li Q, Kobayashi M and Kawada T
    • Organizer
      50^<th> annual meeting of SOT
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      20110305-10
  • [Presentation] Ziram induces apoptosis and necrosis in human immune cells2010

    • Author(s)
      Qing Li, Maiko Kobayashi, Tomoyuki Kawada
    • Organizer
      第17回日本免疫毒性学会
    • Place of Presentation
      筑波
    • Year and Date
      20100900
  • [Presentation] Mechanism of carbamate pesticide-induced inhibition of human NK activity2010

    • Author(s)
      Li Q, Kobayashi M and Kawada T
    • Organizer
      IUTOX 2010
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      20100719-23
  • [Presentation] Effect of oral exposure to fenitrothion and 3-methyl-4-nitrophenol on splenic cell populations and histopathological alterations in spleen in Wistar rats2010

    • Author(s)
      Li Q, Kawada T
    • Organizer
      International Symposium on Occupational and Environmental Allergy and Immune Diseases
    • Place of Presentation
      KYOTO, JAPAN (ISOEAID'10)
    • Year and Date
      20100407-09
  • [Book] Apoptosis (Section-III, Chapter 13): In : Satoh T and Gupta R (eds): Anticholinesterrase Pesticides : Metabolism, Neurotoxicity and Epidemiology2011

    • Author(s)
      Li Q
    • Total Pages
      165-174
    • Publisher
      John Wiley & Sons, USA
  • [Book] NK Cell Assays in Immunotoxicity Testing, Immunotoxicity Testing Methods in series of Molecular Biology2010

    • Author(s)
      Li Q
    • Total Pages
      598:207-1
    • Publisher
      Methods Mol Biol
  • [Remarks]

    • URL

      http://forest-medicine.com

  • [Remarks]

    • URL

      http://tlo.nms.ac.jp/researcher/872.html

URL: 

Published: 2015-07-16  

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