2012 Fiscal Year Final Research Report
Research about the damage of lung exposed by Asian sand dust.
| Project/Area Number |
22590559
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hygiene
|
|---|
| Research Institution | Suzuka University of Medical Science |
|---|
Principal Investigator |
INOUE Sumiko 鈴鹿医療科学大学, 薬学部, 准教授 (20378657)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HIRAKU Yuusuke (30324510)
KAWANISHI Shousuke (10025637)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 黄砂 / 肺細胞 / ICR マウス / 炎症 / 8-ニトログアニン / 8-oxodG |
|---|
| Research Abstract |
The potential pulmonary toxicity by Asian sand dust was investigated. ICR mice were given suspended Asian sand dust with saline by intranasal droplet application once/a week, totally 4 times. Histologically examined lungs showed inflammation by Asian sand dust and association of oxidative stress. Quantitative study by HPLC showed 8-oxodG in lung of mice exposed by Asian sand dust increased significantly. These results suggest that Asian sand dust induces the formation of oxidative species in the lung and leads to inflammation.
|
