Development of systems with endoscopic ultrasonography for diagnosis and treatment of bilio-pancreatic diseases

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590764
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kinki University
• Principal Investigator: KITANO Masayuki 近畿大学, 医学部, 准教授 (50314571)
• Co-Investigator(Kenkyū-buntansha): KUDO Masatoshi 近畿大学, 医学部, 教授 (10298953) ; NISHIO Kazuto 近畿大学, 医学部, 教授 (10208134)
• Project Period (FY): 2010 – 2012
• Keywords: 超音波内視鏡学 / 膵臓病学 / 検査診断システム

Research Abstract

The usefulness of contrast-enhanced harmonic endoscopic ultrasonography for characterization of solid tumors in the pancreas, characterization of intra-abdominal lesions of undetermined origin and estimation of malignant potential of gastrointestinal stromal tumors was evaluated. In comparison with the other imaging methods, this novel technique improved the diagnostic ability for these diseases. Endoscopic ultrasonography guided broad plexus neurolysis achieved better pain relief than endoscopic ultrasonography guided celiac plexus neurolysis. Development of endoscopic ultrasonography guided drainage allowed salvage drainage treatment for obstruction of bilio-pancreatic system after unsuccessful transpapillary or surgical drainage.

Research Products

• [Journal Article] Characterization of small solid tumors in the pancreas: the value of contrast-enhanced harmonic endoscopic ultrasonography (2012)
  • Author(s): Kitano M, Kudo M, Yamao K, Takagi T, Sakamoto H, Komaki T, Kamata K, Imai H, Chiba Y, Okada M, Murakami T, Takeyama Y
  • Journal Title: American Journal of Gastroenterology Volume: 107 Pages: 303-310
  • DOI: DOI: 10.1038/ajg.2011.354.
  • Peer Reviewed
• [Journal Article] Plasma concentrations of angiogenesis-related molecules in patients with pancreatic cancer (2012)
  • Author(s): Sakamoto H, Kimura H, Sekijima M, Matsumoto K, Arao T, Chikugo T, Yamada Y, Kitano M, Ito A, Takeyama Y, Kudo M, Nishio K
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 42 Pages: 105-112
  • DOI: DOI: 10.1093/jjco/hyr178.
  • Peer Reviewed
• [Journal Article] Endoscopic ultrasound: contrast enhancement (2012)
  • Author(s): Kitano M, Sakamoto H, Kudo M
  • Journal Title: Gastrointestinal Endoscopy Clinics of North America Volume: 22 Pages: 349-358
  • DOI: DOI: 10.1016/j.giec.2012.04.013.
  • Peer Reviewed
• [Journal Article] Transcatheter endoscopy for pancreaticobiliary duct diseases (with videos) (2012)
  • Author(s): Sakamoto H, Kitano M, Kamata K, Miyata T, Kadosaka K, Imai H, Takeyama Y, Kudo M
  • Journal Title: Gastrointestinal Endoscopy Volume: 76 Pages: 892-899
  • DOI: DOI: 10.1016/j.gie.2012.06.012.
  • Peer Reviewed
• [Journal Article] Estimation of malignant potential of GI stromal tumors by contrast-enhanced harmonic EUS (with videos) (2011)
  • Author(s): Sakamoto H, Kitano M, Matsui S, Kamata K, Komaki T, Imai H, Dote K, Kudo M
  • Journal Title: Gastrointestinal Endoscopy Volume: 73 Pages: 227-37
  • DOI: DOI: 10.1016/j.gie.2010.10.011.
  • Peer Reviewed
• [Journal Article] Endoscopic ultrasonography and contrast-enhanced endoscopic ultrasonography (2011)
  • Author(s): Kitano M, Kudo M, Sakamoto H, Komaki T
  • Journal Title: Pancreatology Volume: 11 Suppl 2 Pages: 28-33
  • DOI: DOI: 10.1159/000323493.
  • Peer Reviewed
• [Journal Article] Endoscopic ultrasonography-guided biliary drainage: evaluation of a choledochoduodenostomy technique (2011)
  • Author(s): Komaki T, Kitano M, Sakamoto H, Kudo M
  • Journal Title: Pancreatology Volume: 11 Suppl 2 Pages: 47-51
  • DOI: DOI: 10.1159/000323508.
  • Peer Reviewed
• [Journal Article] Endoscopic ultrasound-guided neurolysis in pancreatic cancer (2011)
  • Author(s): Sakamoto H, Kitano M, Komaki T, Imai H, Kamata K, Kudo M
  • Journal Title: Pancreatology Volume: 11 Suppl 2 Pages: 52-58
  • DOI: DOI: 10.1159/000323513.
  • Peer Reviewed
• [Journal Article] New techniques and future perspective of EUS for the differential diagnosis of pancreatic malignancies: contrast harmonic imaging (2011)
  • Author(s): Kitano M, Sakamoto H, Komaki T, Kudo M
  • Journal Title: Digestive Endoscopy Volume: 23 Suppl 1 Pages: 46-50
  • DOI: DOI:10.1111/j.1443-1661.2011.01146.x.
  • Peer Reviewed
• [Journal Article] Pancreatic ductal drainage by endoscopic ultrasound-assisted rendezvous technique for pain caused by ductal stricture with chronic pancreatitis. (2010)
  • Author(s): Das K, Kitano M, Komaki T, Sakamoto H, Noda K, Suetomi Y, Kudo M
  • Journal Title: Digestive Endoscopy Volume: 22 Pages: 217-219
  • DOI: DOI:10.1111/j.1443-1661.2010.00980.x.
  • Peer Reviewed
• [Journal Article] Characterization of intra-abdominal lesions of undetermined origin by contrast-enhanced harmonic EUS (with videos) (2010)
  • Author(s): Xia Y, Kitano M, Kudo M, Imai H, Kamata K, Sakamoto H, Komaki T
  • Journal Title: Gastrointestinal Endoscopy Volume: 72 Pages: 637-642
  • DOI: DOI: 10.1016/j.gie.2010.04.013.
  • Peer Reviewed
• [Journal Article] Diagnosis of pancreatic tumors by endoscopic ultrasonography (2010)
  • Author(s): Sakamoto H, Kitano M, Kamata K, El-Masry M, Kudo M
  • Journal Title: World Journal of Radiology Volume: 28 Pages: 122-134
  • DOI: DOI: 10.4329/wjr.v2.i4.122.
  • Peer Reviewed
• [Journal Article] Diagnosis of subepithelial tumors in the upper gastrointestinal tract by endoscopic ultrasonography (2010)
  • Author(s): Sakamoto H, Kitano M, Kudo M
  • Journal Title: World Journal of Radiology Volume: 28 Pages: 289-297
  • DOI: DOI: 10.4329/wjr.v2.i8.289.
  • Peer Reviewed
• [Journal Article] Endoscopic ultrasound (EUS)-guided transluminal endoscopic removal of gallstones (2010)
  • Author(s): Kamata K, Kitano M, Kudo M, Imai H, Sakamoto H, Komaki T
  • Journal Title: Endoscopy Volume: 42 Suppl 2 Pages: E331-332
  • DOI: DOI: 10.1055/s-0030-1255941.
  • Peer Reviewed
• [Journal Article] EUS-guided broad plexus neurolysis over the superior mesenteric artery using a 25-gauge needle (2010)
  • Author(s): Sakamoto H, Kitano M, Kamata K, Komaki T, Imai H, Chikugo T, Takeyama Y, Kudo M
  • Journal Title: American Journal of Gastroenterology Volume: 105 Pages: 2599-2606
  • DOI: DOI: 10.1038/ajg.2010.339.
  • Peer Reviewed
• [Presentation] Therapeutic EUS - expanding horizons (Invited lecture) (2013)
  • Author(s): Kitano M
  • Organizer: 14th Annual Conference of Society of Gastrointestinal Endoscopy in India
  • Place of Presentation: Gurgaon, India
  • Year and Date: 20130301-03
• [Presentation] Contrast enhanced EUS & elastography (Invited lecture) (2012)
  • Author(s): Kitano M
  • Organizer: The 6th Meeting of the Society of Gastrointestinal Intervention
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20121005-06
• [Presentation] Better imaging, better diagnosis? (Invited lecture) (2012)
  • Author(s): Kitano M
  • Organizer: 18th International Symposium on Endoscopic Ultrasonography
  • Place of Presentation: Saint Petersburg, Russia
  • Year and Date: 20120906-08
• [Presentation] Drastic improvement of patency of covered self-expandable metal stents for distal billiary obstruction caused by pancreatic carcinomas: a randomized multicenter study comparing covered and uncovered stents (2012)
  • Author(s): Kitano M
  • Organizer: Digestive Disease Week 2012
  • Place of Presentation: San Diego、USA
  • Year and Date: 20120519-22
• [Presentation] EUS-guided drainage for biliary obstruction after unsuccessful ERCP (2012)
  • Author(s): Kitano M
  • Organizer: 第83回日本消化器内視鏡学会総会
  • Place of Presentation: 東京
  • Year and Date: 20120512-14
• [Presentation] 造影ハーモニックEUS システムの開発と臨床応用 (2011)
  • Author(s): 北野雅之
  • Organizer: 第81回日本消化器内視鏡学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 20110817-19
• [Presentation] Contrast-enhance harmonic EUS in diagnosing pancreatic neoplasms (2011)
  • Author(s): Kitano M
  • Organizer: 第81回日本消化器内視鏡学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 20110817-19
• [Presentation] EUS-guided gallbladder drainage as an alternative treatment for malignant biliary obstruction after unsuccessful ERCP: Outcomes of long term follow-up (2011)
  • Author(s): Kitano M
  • Organizer: Digestive Disease Week 2011
  • Place of Presentation: Chicago、USA
  • Year and Date: 20110507-10
• [Presentation] Characterization of small pancreatic neoplasms by contrast-enhanced harmonic EUS (2010)
  • Author(s): Kitano M
  • Organizer: 18th United European Gastroenterology Week
  • Place of Presentation: Barcelona、Spain
  • Year and Date: 20101023-27
• [Presentation] EUS ガイド下治療のコツと工夫 (2010)
  • Author(s): 北野雅之
  • Organizer: 第80回日本消化器内視鏡学会総会
  • Place of Presentation: 横浜
  • Year and Date: 20101013-16
• [Presentation] Contrast-enhanced harmonic endosonography in diagnosing pancreatic diseases (2010)
  • Author(s): Kitano M
  • Organizer: Joint Meeting of the International Association of Pancreatology and the Japan Pancreas Society
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 20100711-13
• [Presentation] 膵疾患に対する超音波内視鏡ガイド下ドレナージ術 (2010)
  • Author(s): 北野雅之
  • Organizer: 日本超音波医学会 第83回学術集会
  • Place of Presentation: 京都
  • Year and Date: 20100529-31
• [Presentation] Contrast-enhanced harmonic EUS for diagnosis of pancreatic tumors (2010)
  • Author(s): Kitano M
  • Organizer: 第79回日本消化器内視鏡学会総会
  • Place of Presentation: 東京
  • Year and Date: 20100513-15
• [Presentation] EUS-guided choledochoduodenostomy followed by endoscopic antegrade biliary stenting via the fistula for treatment of obstructive jaundice with duodenal stenosis (2010)
  • Author(s): Kitano M
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: New Orleans、USA
  • Year and Date: 20100501-05
• [Presentation] EUS-guided gallbladder drainage for treatment of acute cholecystitis and obstructive jaundice (2010)
  • Author(s): Kitano M
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: New Orleans、USA
  • Year and Date: 20100501-05
• [Book] Interventional EUS の極意「EUS-GBD のコツ」. 胆膵内視鏡治療-手技の極意とトラブルシューティング(分担執筆) (2012)
  • Author(s): 北野雅之
  • Total Pages: 148-151
  • Publisher: 羊土社
• [Book] 超音波内視鏡ガイド下穿刺術. 消化器内視鏡ハンドブック(分担執筆) (2012)
  • Author(s): 北野雅之, 他
  • Total Pages: 111-122
  • Publisher: 日本メディカルセンター
• [Book] 拡張膵管に対する治療. EUS 下穿刺術-Interventional EUS の基礎と実践テクニック-(分担執筆) (2011)
  • Author(s): 北野雅之
  • Total Pages: 157-163
  • Publisher: 南江堂
• [Book] 膵癌の診断と治療方針・疼痛対策. 今日の消化器疾患治療指針(分担執筆) (2010)
  • Author(s): 北野雅之、工藤正俊
  • Total Pages: 773-776
  • Publisher: 医学書院