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2012 Fiscal Year Final Research Report

Clinical Assessment of Endothelial Dysfunction and Investigationof New Therapies in Cardiovascular Diseases

Research Project

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Project/Area Number 22590786
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKumamoto University

Principal Investigator

SUGIYAMA Seigo  熊本大学, 大学院・生命科学研究部, 准教授 (90274711)

Project Period (FY) 2010 – 2012
Keywords臨床心血管病態学 / 血管内皮細胞障害 / 冠動脈疾患 / 心不全 / 心血管イベント / 危険因子 / 動脈硬化
Research Abstract

We examined Reactive Hyperemia Peripheral Arterial Tonometry(RH-PAT) test and measurement of plasma levels of Endothelium-derived Microparticles(EMP) in patients suspected with coronary artery disease and heart failure patients inorder to assess vascular endothelial dysfunction clinically. We found CD144-EMP was anindependent prognostic factor for cardiovascular events in patients with heart failurewith reduced LVEF. We demonstrated the presence of coronary endothelial dysfunction andidentified distinctive clinical features in patients with coronary microvascular spasticangina. The vascular endothelial function assessed by RH-PAT test in patients with heartfailure with normal LVEF (HFNEF) was a significant and independent factor of the futurecardiovascular events. We demonstrated that the treatment by DPP-IV inhibitor(Sitagliptin); a new medicine for diabetes, improved the vascular endothelial functionand significantly inhibited atherosclerosis formation in the ApoE deficiency mouse, amouse model of atherosclerosis.

  • Research Products

    (22 results)

All 2013 2012 2011 2010

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (6 results)

  • [Journal Article] Basal andischemia-induced transcardiac troponinrelease into the coronary circulationin patients with suspected coronaryartery disease2013

    • Author(s)
      Konishi M, Sugiyama S, Sugamura K,Nozaki T, Ohba K, Matsubara J, SakamotoK, Nagayoshi Y, Sumida H, Akiyama E,Matsuzawa Y, Sakamaki K, Morita S,Kimura K, Umemura S, Ogawa H
    • Journal Title

      PLoS One

      Volume: 8(4) Pages: e60163

    • DOI

      DOI:10.1371/journal.pone.0060163

    • Peer Reviewed
  • [Journal Article] Dipeptidyl Peptidase-4 Inhibitor,Sitagliptin, Improves EndothelialDysfunction in Association With ItsAnti-Inflammatory Effects in PatientsWith Coronary Artery Disease andUncontrolled Diabetes2013

    • Author(s)
      Matsubara J, Sugiyama S, Akiyama E,Iwashita S, Kurokawa H, Ohba K, Maeda H,Fujisue K, Yamamoto E, Kaikita K,Hokimoto S, Jinnouchi H, Ogawa H
    • Journal Title

      Circ J

      Volume: 77 Pages: 1337-1344

    • DOI

      DOI:10.1253/circ.CJ-12-1168

    • Peer Reviewed
  • [Journal Article] Microvascular coronary artery spasmpresents distinctive clinical featureswith endothelial dysfunction asnonobstructive coronary artery disease2012

    • Author(s)
      Ohba K, Sugiyama S, Sumida H, Nozaki T, Matsubara J, Matsuzawa Y, Konishi M, Akiyama E, Kurokawa H, Maeda H, Sugamura K, Nagayoshi Y, Morihisa K, Sakamoto K, Tsujita K, Yamamoto E, Yamamuro M, Kojima S, Kaikita K, Tayama S, Hokimoto S, Matsui K, Sakamoto T, Ogawa H
    • Journal Title

      J Am Heart Assoc

      Volume: 1(5) Pages: e002485

    • DOI

      DOI:10.1161/JAHA.112.002485

    • Peer Reviewed
  • [Journal Article] Incremental prognostic significance ofperipheral endothelial dysfunction inpatients with heart failure with normalleft ventricular ejection fraction2012

    • Author(s)
      Akiyama E, Sugiyama S, Matsuzawa Y,Konishi M, Suzuki H, Nozaki T, Ohba K,Matsubara J, Maeda H, Horibata Y,Sakamoto K, Sugamura K, Yamamuro M,Sumida H, Kaikita K, Iwashita S, MatsuiK, Kimura K, Umemura S, Ogawa H
    • Journal Title

      JAm Coll Cardiol

      Volume: 60(18) Pages: 1778-86

    • DOI

      DOI:10.1016/j.jacc.2012.07.036

    • Peer Reviewed
  • [Journal Article] Combination treatment ofrosuvastatin or atorvastatin, withregular exercise improves arterial wallstiffness in patients with coronaryartery disease2012

    • Author(s)
      Toyama K, Sugiyama S, Oka H, Iwasaki Y,Sumida H, Tanaka T, Tayama S, JinnouchiH, Ogawa H
    • Journal Title

      PLoS One

      Volume: 7(7) Pages: e41369

    • DOI

      DOI:10.1371/journal.pone.0041369

    • Peer Reviewed
  • [Journal Article] Accumulation of pericardial fatcorrelates with left ventriculardiastolic dysfunction in patients withnormal ejection fraction2012

    • Author(s)
      Konishi M, Sugiyama S, Sugamura K,Nozaki T, Matsubara J, Akiyama E,Utsunomiya D, Matsuzawa Y, Yamashita Y,Kimura K, Umemura S, Ogawa H
    • Journal Title

      J Cardiol

      Volume: 59(3) Pages: 344-51

    • DOI

      DOI:10.1016/j.jjcc.2012.01.006

    • Peer Reviewed
  • [Journal Article] A dipeptidylpeptidase-4 inhibitor,des-fluoro-sitagliptin, improvesendothelial function and reducesatherosclerotic lesion formation inapolipoprotein E-deficient mice2012

    • Author(s)
      Matsubara J, Sugiyama S, Sugamura K,Nakamura T, Fujiwara Y, Akiyama E,Kurokawa H, Nozaki T, Ohba K, Konishi M,Maeda H, Izumiya Y, Kaikita K, Sumida H,Jinnouchi H, Matsui K, Kim-Mitsuyama S,Takeya M, Ogawa H
    • Journal Title

      J AmColl Cardiol

      Volume: 59(3) Pages: 265-76

    • DOI

      DOI:10.1016/j.jacc.2011.07.053

    • Peer Reviewed
  • [Journal Article] Total coronaryartery plaque burden measured bycardiac computed tomography isassociated with metabolic syndrome2011

    • Author(s)
      Konishi M, Sugiyama S, Sugamura K,Nozaki T, Ohba K, Matsubara J, Sumida H,Nagayoshi Y, Utsunomiya D, Awai K,Yamashita Y, Matsuzawa Y, Kimura K,Umemura S, Ogawa H
    • Journal Title

      JAtheroscler Thromb

      Volume: 18(11) Pages: 939-45

    • Peer Reviewed
  • [Journal Article] Improvement effect on endothelialfunction in patients with congestiveheart failure treated with cardiacresynchronization therapy2011

    • Author(s)
      Enomoto K, Yamabe H, Toyama K, MatsuzawaY, Yamamuro M, Uemura T, Morihisa K,Iwashita S, Kaikita K, Sugiyama S, OgawaH
    • Journal Title

      J Cardiol

      Volume: 58(1) Pages: 69-73

    • DOI

      DOI:10.1016/j.jjcc.2011.01.010

    • Peer Reviewed
  • [Journal Article] Rosuvastatincombined with regular exercisepreserves coenzyme Q10 levelsassociated with a significant increase in high-density lipoproteincholesterol in patients with coronaryartery disease2011

    • Author(s)
      Toyama K, Sugiyama S, Oka H, Iwasaki Y,Sumida H, Tanaka T, Tayama S, JinnouchiH, Matsui K, Ogawa H
    • Journal Title

      Atherosclerosis

      Volume: 217(1) Pages: 158-64

    • DOI

      DOI:10.1016/j.atherosclerosis.2011.02.050

    • Peer Reviewed
  • [Journal Article] Pentraxin 3 isa new inflammatory marker correlatedwith left ventricular diastolicdysfunction and heart failure withnormal ejection fraction2011

    • Author(s)
      Matsubara J, Sugiyama S, Nozaki T,Sugamura K, Konishi M, Ohba K, MatsuzawaY, Akiyama E, Yamamoto E, Sakamoto K,Nagayoshi Y, Kaikita K, Sumida H,Kim-Mitsuyama S, Ogawa H
    • Journal Title

      J Am CollCardiol

      Volume: 57(7) Pages: 861-9

    • DOI

      DOI:10.1016/j.jacc.2010.10.018

    • Peer Reviewed
  • [Journal Article] Pericardial fat inflammationcorrelates with coronary artery disease2010

    • Author(s)
      Konishi M, Sugiyama S, Sato Y, Oshima S,Sugamura K, Nozaki T, Ohba K, MatsubaraJ, Sumida H, Nagayoshi Y, Sakamoto K,Utsunomiya D, Awai K, Jinnouchi H,Matsuzawa Y, Yamashita Y, Asada Y,Kimura K, Umemura S, Ogawa H
    • Journal Title

      Atherosclerosis

      Volume: 213(2) Pages: 649-55

    • DOI

      DOI:10.1016/j.atherosclerosis.2010.10.007

    • Peer Reviewed
  • [Journal Article] Prognostic value ofendothelial microparticles in patientswith heart failure2010

    • Author(s)
      Nozaki T, Sugiyama S, Sugamura K, OhbaK, Matsuzawa Y, Konishi M, Matsubara J,Akiyama E, Sumida H, Matsui K, JinnouchiH, Ogawa H
    • Journal Title

      Eur J Heart Fail

      Volume: 12(11) Pages: 1223-8

    • DOI

      DOI:10.1093/eurjhf/hfq145

    • Peer Reviewed
  • [Journal Article] Exercise therapy correlateswith improving renal function throughmodifying lipid metabolism in patientswith cardiovascular disease and chronickidney disease2010

    • Author(s)
      Toyama K, Sugiyama S, Oka H, Sumida H,Ogawa H
    • Journal Title

      J Cardiol

      Volume: 56(2) Pages: 142-6

    • DOI

      DOI:10.1016/j.jjcc.2010.06.007

    • Peer Reviewed
  • [Journal Article] Digitalassessment of endothelial function andischemic heart disease in women2010

    • Author(s)
      Matsuzawa Y, Sugiyama S, Sugamura K,Nozaki T, Ohba K, Konishi M, MatsubaraJ, Sumida H, Kaikita K, Kojima S,Nagayoshi Y, Yamamuro M, Izumiya Y,Iwashita S, Matsui K, Jinnouchi H,Kimura K, Umemura S, Ogawa H
    • Journal Title

      J AmColl Cardiol

      Volume: 55(16) Pages: 1688-96

    • DOI

      DOI:10.1016/j.jacc.2009.10.073

    • Peer Reviewed
  • [Journal Article] Association of pericardial fataccumulation rather than abdominalobesity with coronary atheroscleroticplaque formation in patients withsuspected coronary artery disease2010

    • Author(s)
      Konishi M, Sugiyama S, Sugamura K、Nozaki T, Ohba K, Matsubara J, MatsuzawaY, Sumida H, Nagayoshi Y, Nakaura T,Awai K, Yamashita Y, Jinnouchi H, MatsuiK, Kimura K, Umemura S, Ogawa H
    • Journal Title

      Atherosclerosis

      Volume: 209(2) Pages: 573-8

    • DOI

      DOI:10.1016/j.atherosclerosis.2009.10.008.

    • Peer Reviewed
  • [Presentation] How to Reduce Residual Riskin Patients with DM in the Statin Era?2013

    • Author(s)
      杉山 正悟
    • Organizer
      第77回日本循環器学会学術集会(招待講演)
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2013-03-19
  • [Presentation] 血管内皮機能検査から全身を診る 「血管内皮機能検査による心血管リスクの評価の実際と臨床応用2012

    • Author(s)
      杉山 正悟
    • Organizer
      第60回日本心臓病学会学術集会 (招待講演)
    • Place of Presentation
      ホテル日航金沢、金沢市
    • Year and Date
      2012-09-16
  • [Presentation] 血管病変の非侵襲的評価法の有用性2012

    • Author(s)
      杉山 正悟
    • Organizer
      第60回日本心臓病学会学術集会 (招待講演)
    • Place of Presentation
      ホテル日航金沢、 金沢市
    • Year and Date
      2012-09-14
  • [Presentation] 拡張不全と炎症2012

    • Author(s)
      杉山 正悟
    • Organizer
      第76回日本循環器学会学術集会(招待講演)
    • Place of Presentation
      福岡 福岡国際会議場
    • Year and Date
      2012-03-17
  • [Presentation] 新しい炎症マーカーである Pentraxin3 と拡張障害2011

    • Author(s)
      杉山 正悟
    • Organizer
      拡張障害性心不全との関係 第15回日本心不全学会学術集会(招待講演)
    • Place of Presentation
      鹿児島 かごしま県民交流センター
    • Year and Date
      2011-10-13
  • [Presentation] ガス分子による血管内皮機能調節~血管内皮機能測定の意義と問題点2011

    • Author(s)
      杉山 正悟
    • Organizer
      第11回日本NO学会学術集会(招待講演)
    • Place of Presentation
      東京 昭和薬科大学
    • Year and Date
      2011-05-14

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Published: 2014-08-29  

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