Role of chitinase like protein in chronic inflammatory airway diseases

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590839
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kyoto University
• Principal Investigator: MATSUMOTO Hisako 京都大学, 医学研究科, 助教 (60359809)
• Co-Investigator(Kenkyū-buntansha): ITO Yutaka (80362482) ; HIRATA Yutaka (10441247) ; OKU Yoshitaka (20252512)
• Project Period (FY): 2010 – 2012
• Keywords: 難治性気道疾患 / キチナーゼ関連タンパク質 / 喘息

Research Abstract

The mechanisms underlying airway remodeling accompanying with non-eosinophilic airway inflammation remain unclear. Chitinase-like protein, YKL-40 that is also known as age-related protein, is produced from various cells including airway epithelial cells, neutrophils, and macrophages. This study demonstrated that YKL-40 accelerates proliferation of cultured airway smooth muscle cells and may also alter the proportion of extracellular matrix. Thus YKL-40 may be involved in the pathogenesis of airway remodeling in elderly patients with asthma or COPD, where non-eosinophilic airway inflammation is predominant.

Research Products

• [Journal Article] Effects of 24-week add-on treatment with ciclesonide and montelukast on small airways inflammation in asthma (2013)
  • Author(s): Nakaji H, Petrova G, Matsumoto H, Iwata T, Ito I, Oguma T, Inoue H, Tajiri T, Nagasaki T, Kanemitsu Y, Niimi A, Misima M
  • Journal Title: Ann Allergy Asthma Immunol Volume: 110 Pages: 198-203
• [Journal Article] Interleukin-13 enhanced Ca2+oscillations in airway smooth muscle cells (2012)
  • Author(s): Matsumoto H, Hirata Y, Oku Y. et al
  • Journal Title: Cytokine Volume: 57 Pages: 19-24
• [Journal Article] Sputum YKL-40 levels and pathophysiology of asthma and chronic obstructive pulmonary disease (2012)
  • Author(s): Otsuka K, Matsumoto H, et al
  • Journal Title: Respiration Volume: 83 Pages: 507-19
• [Journal Article] Smoking attenuates the age-related decrease in IgE levels and maintains eosinophilic inflammation
  • Author(s): Nagasaki T, Matsumoto H, et al
  • Journal Title: Clin Exp Allergy
  • DOI: DOI:10.1111/cea.12073
• [Journal Article] Association of eosinophilic inflammation with FKBP51 expression in sputum cells in asthma
  • Author(s): Tajiri T, Matsumoto H, et al
  • Journal Title: PLOS one
• [Journal Article] Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids
  • Author(s): Kanemitsu Y, Matsumoto H, et al
  • Journal Title: J Allergy Clin Immunol
• [Presentation] Associations of asthma control status with inflammatory biomarkers: "Shortness of breath" and serum YKL-40 levels
  • Author(s): H. Nakaji, H. Matsumoto, A. Niimi, I. Ito, H. Inoue, T. Iwata, T. Oguma, T. Tajiri, T. Nagasaki, M. Mishima
  • Organizer: 2012 American Thoracic Society
• [Presentation] Effects of 24-week add-on treatment with ciclesonide and montelukast on small airways inflammation in asthma
  • Author(s): Matsumoto H, Nakaji H, Petrova G, Iwata T, Ito I, Oguma T, Inoue H, Tajiri T, Nagasaki T, Kanemitsu Y, Niimi A, Misima M
  • Organizer: 2013 American Thoracic Society