2012 Fiscal Year Final Research Report
Development of a new immunosuppressive therapy using adipose derived mesenchymal stem cell
| Project/Area Number |
22590887
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
OZAKI Takenori 名古屋大学, 医学部附属病院, 病院助教 (10452195)
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Shoichi 名古屋大学, 大学院・医学系研究科, 准教授 (10362253)
YUZAWA Yukio 藤田保健衛生大学, 医学部, 教授 (00191479)
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| Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI Takaaki 名古屋大学, 大学院・医学系研究科, 寄附講座教授 (70314010)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脂肪由来間葉系幹細胞 / 低血清培養 / 抗糸球体基底膜抗体腎炎 / 強皮症 / M2 マクロファージ |
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| Research Abstract |
We clarified that administration of low serum cultured adipose derived mesenchymal stem cells (MSCs) showed therapeutic effect on animal models including rat anti-GBM glomerulonephritis and mouse systemic sclerosis. We demonstrated that low serum cultured adipose derived MSCs may exert immnosuppressive effect by inducing M2 macrophages. We also found that low serum cultured adipose derived MSCs did not promote malignant tumorigenesis and administration of 7×10^7/kg cells was safe.
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