2012 Fiscal Year Final Research Report
Metabolic regulation by adipose tissue macrophage and interleulin-10
| Project/Area Number |
22590971
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | University of Toyama |
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Principal Investigator |
USUI Isao 富山大学, 大学病院, 講師 (50377272)
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| Co-Investigator(Kenkyū-buntansha) |
TOBE Kazuyuki 富山大学, 大学院・医学薬学研究部(医学), 教授 (30251242)
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| Co-Investigator(Renkei-kenkyūsha) |
MINOKOSHI Yasuhiko 生理学研究所, 発達生理学研究系, 教授 (10200099)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 内科系臨床医学 / 代謝学 |
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| Research Abstract |
In this study, we investigated the relationship between adipose tissue M1/M2 macrophages and insulin sensitivity, focusing on the roles of M2 macrophage and interleukin10 （IL-10). Telmisartan, an angiotensin II type I receptor blocker, induced M2 polarity of adipose tissue macrophages with its PPARγ-stimulating activity, while adipose tissue hypoxia induced the M1 polarity. M2 macrophage ablation mice, in which the number of M2 macrophage could be decreased by adding diphtheria toxin, showed smaller adipocyte size and improved insulin sensitivity. The activation of IL-10 signaling in hypothalamus increased the expression of mitochondria-related genes in skeletal muscle and improved inulin sensitivity.
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Research Products
(20 results)
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[Journal Article] Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice.2013
Author(s)
Fujisaka S, Usui I, Ikutani M, Aminuddin A, Takikawa A, Tsuneyama K, Mahmood A, Goda N, Nagai Y, Takatsu K, Tobe K.
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Journal Title
Diabetologia
Volume: 56(6)
Pages: 1403-12
Peer Reviewed
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[Journal Article] The Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation2012
Author(s)
Watanabe Y., Nakamura T., Ishikawa S., Fujisaka S., Usui I., Tsuneyama K., Ichihara Y., Wada T., Hirata Y., Suganami T., Izaki H., Akira S., Miyake K., Kanayama H., Shimabukuro M., Sata M., Sasaoka T.,Ogawa Y., Tobe K., Takatsu K., and Nagai Y.
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Journal Title
Diabetes.
Volume: 61(5)
Pages: 1199-209
Peer Reviewed
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[Journal Article] Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice2011
Author(s)
Fujisaka S., Usui I., Kanatani Y., Ikutani M., Takasaki I., Tsuneyama K., Tabuchi Y., Bukhari A., Yamazaki Y., Suzuki H., Senda S., Aminuddin A., Nagai Y., Takatsu K., Kobayashi M., To be K.
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Journal Title
Endocrinology
Volume: 152(5)
Pages: 1789-99
Peer Reviewed
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[Journal Article] Deletion of platelet-derived growth factor receptor-βimproves diabetic nephropathy in Ca2+/calmodulin-dependent protein kinase II α (Thr286 Asp) transgenic mice2011
Author(s)
Suzuki H., Usui I., Kato I., Oya T., Kanatani Y., Yamazaki Y., Fujisaka S., Senda S., Ishii Y., Urakaze M., Mahmood A., Takasawa S., Okamoto H., Kobayashi M., To be K., Sasahara M
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Journal Title
Diabetologia
Volume: 54
Pages: 2953-2962
Peer Reviewed
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[Presentation] Impact of Adipose Tissue Hypoxia on Macriphage Polarization in Diet-induced Obese Mice.2012
Author(s)
Fujisaka S., Usui I., Ikutani M., Aminuddin A., Senda S., Takikawa A., Ishiki M., Koshimizu Y., Tsuneyama K., Nagai Y., Takatsu K., To be K.
Organizer
American Diabetes Association 72nd Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-09
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[Presentation] Myeloid Cell-specific Deletion of SIRT1 Impairs Glucose Metabolism wiht Enhanced Inflammatory Response to Hypoxia2012
Author(s)
Takikawa A., Usui I., Senda S., Fujisaka S., Hattori S., Tsuneyama K., Aminuddin A., Mahmood A., Sasaoka T., Mori H., To be K.
Organizer
American Diabetes Association 72nd Scientific Sessions
Place of Presentation
Philadelphia, USA
Year and Date
2012-06-09
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[Presentation] Hyperleptinemia induces leptin resistancce and further worsening obesity2011
Author(s)
Senda S., Inoue A., Suzuki R., Kamei N., Watanabe T., Mahmood A., Takikawa A., Aminuddin A., Fujisaka S., Koshimizu Y., Ishiki M., Usui I., Kadowaki T., To be K.
Organizer
American Diabetes Association's 71st Scientific Sessions
Place of Presentation
San Diego, USA
Year and Date
2011-06-26
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[Presentation] Obesity-induced hypoxia regulates the polarization of adipose tissue macrophages.2011
Author(s)
FujisakaS., UsuiI., Ikutani M., Kanatani Y., Senda S., TakikawaA., Aminuddin, SuzukiH., IshikiM., IwataM., NagaiY., TakatsuK., To be K
Organizer
American Diabetes Association's 71st Scientific Sessions
Place of Presentation
San Diego, USA
Year and Date
2011-06-26
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