2012 Fiscal Year Final Research Report
The role of stretch signal induced by the adipocytes hypertrophy and activation of Rho/Rho kinase pathway in the pathogenesis of obesity
| Project/Area Number |
22591017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Keio University |
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Principal Investigator |
WAKINO Shu 慶應義塾大学, 医学部, 講師 (50265823)
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Hiroshi 慶應義塾大学, 医学部, 教授 (40252457)
TANABE Yoshiyuki 岩手医科大学, 薬学部, 准教授 (10275109)
SAITO Maki 岩手医科大学, 薬学部, 助教 (40365185)
TOKUYAMA Hiroumi 慶應義塾大学, 医学部, 講師 (50276250)
HARA Yoshikazu 慶應義塾大学, 医学部, 助教 (30383863)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 内科 / シグナル伝達 / 肥満 |
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| Research Abstract |
The development of obesity involves multiple mechanisms. Here we demonstrate adipocyte Rho/Rho-kinase as a culprit in obesity. In high fat diet (HFD)-fed mice, Rho-kinase inhibitor treatment prevented body weight gain and insulin resistance. Transgenic mi
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Research Products
(13 results)
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[Journal Article] Role of mineralocorticoid receptor/Rho/Rho-kinase pathway in obesity-related renal injury2012
Author(s)
Tokuyama H, Wakino S, Hara Y, Washida N, Fujimura K, Hosoya K, Yoshioka K, Hasegawa K, Minakuchi H, Homma K, Hayashi K, Itoh H.
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Journal Title
Int J Obes
Volume: 36(8)
Pages: 1062-71
Peer Reviewed
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[Journal Article] Itoh H Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch.2010
Author(s)
Hara Y, Wakino S, Tanabe Y, Saito M, Tokuyama H, Washida N, Tatematsu S, Yoshioka K, Homma K, Hasegawa K, Minakuchi H, Fujimura K, Hosoya K, Hayashi K, Nakayama K
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Journal Title
Science Signaling
Volume: 4(157)
Pages: 1-10
Peer Reviewed
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