2012 Fiscal Year Final Research Report
Molecular mechanism of the therapy-related myeloid neoplasms
| Project/Area Number |
22591038
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Hiroshima University |
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Principal Investigator |
HARADA Yuka 広島大学, 原爆放射線医科学研究所, 助教 (50379848)
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| Co-Investigator(Kenkyū-buntansha) |
HARADA Hironori 広島大学, 原爆放射線医科学研究所, 講師 (10314775)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 治療関連造血器腫瘍 / 遺伝子異常 / 急性前骨髄球性白血病 / RUNX1 / 骨髄異形成症候群 / MLL / エトポシド / BMI1 |
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| Research Abstract |
We analyzed genetic abnormalities in the patients with therapy-related myeloid neoplasms (t-MN), and found that gene abnormalities of RUNX1 orMLL gene were the most common molecular abnormalities in t-MN after acute promyelocytic leukemia treated with VP16. VP16-treated cells showed rearrangement bands in both RUNX1 and MLL genes, suggesting that it may result in subsequent development of t-MN. Furthermore, we verified that RUNX1 mutant collaborates with BMI1 overexpression in the development of t-MDS/AML.
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[Journal Article] RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes2013
Author(s)
Harada Y, Inoue D, Ding Y, Imagawa J, Doki N, Matsui H, Yahata T, Matsushita H, Ando K, Sashida G, Iwama A, Kitamura T, Harada H
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Journal Title
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[Journal Article] 骨髄異形成症候群(MDS)と慢性骨髄性白血病(CML)における白血病移行の分子機構.第73回日本血液学会学術集会シンポジウム 112012
Author(s)
北村俊雄,大河内直子,井上大地,戸上勝仁,内田智之,鍵山侑希,川畑公人,千葉 滋,原田結花,原田浩徳,北浦次郎,中原史雄
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Journal Title
臨床血液
Volume: 53(8)
Pages: 734-739
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