2012 Fiscal Year Final Research Report
Novel functions and Mechanisms of Coagulation Factor XIII/13 in the Platelet/Fibrin Clot Retraction Reaction
| Project/Area Number |
22591058
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SOURI Masayoshi 山形大学, 医学部, 准教授 (20292419)
OSAKI Tukasa 山形大学, 医学部, 助教 (60380565)
KOHJI Kasahara (公財)東京都医学総合研究所, 細胞膜研究室, 副室長 (60250213)
YATOMI Yutaka 東京大学, 医学部附属病院, 教授 (60200523)
IWATA Hiroki 山形大学, 医学部, 助教 (70361251)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 第XIII因子 / 架橋結合 / 血小板 / フィブリン / 血餅退縮 |
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| Research Abstract |
The results of our 3-years studies strongly suggested that intracellular factor XIII (FXIII)A-subunit (FXIII-A) plays a role(s) in the proliferation and differentiation of monocytes/macrophages and megakaryocytes/platelets. It was clearly demonstrated thatextracellular FXIII-A activated the platelet signal transduction system(s) and inducedplatelet/fibrin clot retraction via biding to glycoprotein IIb/IIIa (Submitted). However, we could not conclude whether or not intracellular FXIII-A was essential in this reaction.
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[Presentation] Translocation of Fibrin and myosin intoplatelet membrane rafts is an importantprocess for clot retraction via afunctional property of GPIIB/IIIA2011
Author(s)
Kasahara K, Kaneda M, Miki T, Iida K, Suzuki H, Hara Y, Shimonaka M, Arai M, Kobayashi T, Ichinose A, Yamamoto N
Organizer
XXIIICongress of the International Society onThrombosis and Haemostasis (ISTH2011) and 57th Annual SSC Meeting
Place of Presentation
KyotoInternational Conference Center (Kyoto,Japan)
Year and Date
20110723-28
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[Presentation] フィブリンの血小板脂質ラフト移行と血餅退縮における働き2010
Author(s)
笠原浩二 ,兼田瑞穂 ,三木俊明 ,飯田和子,鈴木英紀 ,原裕太 ,下仲基之 ,小嶋聡一,新井盛大 ,惣宇利正善 ,一瀬白帝 ,山本正雅
Organizer
第48回東北止血・血栓研究会
Place of Presentation
山形テルサ(山形)
Year and Date
2010-09-04
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