Prospective study of the prevalence of neuropsychiatric lupus erythematosus (NPSLE) manifestation among patients with SLE in Tochigi prefecture from 2010 to 2012 and the intrathecal production of IL-6, IL-8, IP-10, MCP-1 and G-CSF increase more highly tha

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591081
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Jichi Medical University
• Principal Investigator: YOSHIO Taku 自治医科大学, 医学部, 教授 (20221666)
• Research Collaborator: KURASAWA Kazuhiro 独協医科大学, 医学部, 教授 (30282479) ; DEI Yoshiaki 済生会宇都宮病院, 医長 ; OKAMOTO Hiroshi 南大塚クリニック, 院長 (10260100) ; HIROHATA Shunsei 北里大学, 医学部, 教授 (90189895) ; MINOTA Seiji 自治医科大学, 医学部, 教授 (30211593)
• Project Period (FY): 2010 – 2012
• Keywords: 全身性エリテマトーデス / 中枢神経ループス / ループス精神病 / 髄液 / サイトカイン / ケモカイン / 血液脳関門 / インターロイキン6

Research Abstract

1. Prospective study of the prevalence of NPSLE manifestation among patients with SLE in Tochigi from 2010 to 2012: 719 SLE patients were enrolled at the first of studyand 823 enrolled patients were confirmed at the end of study. Prevalence of SLE patient
2. The intrathecal production of IL-6, IL-8, IP-10, MCP-1 and G-CSF increase more highly than the serum production in patients with NPSLE: 52 SLE patients, of whom the CSF and serum samples were obtained at the same time, were enrolled. Of 52 SLE patients

Research Products

• [Journal Article] IgG anti-NR2 glutamate receptor autoantibodies from patients with systemic lupus erythematosus activate endothelial cells (2013)
  • Author(s): Yoshio T, Okamoto H, Hirohata S, Minota S
  • Journal Title: Arthritis Rheum Volume: 65 Pages: 457-63
• [Journal Article] An unusual cause of hemichorea-hemiballism in a patient with systemic lupus erythematosus. (2013)
  • Author(s): Maruyama A, Nagashima T, Kamata Y, Nagatani K, Murosaki T, Yoshio T, Minota S
  • Journal Title: Rheumatol Int Volume: 33 Pages: 267-8
• [Journal Article] Systemic lupus erythematosus. (2012)
  • Author(s): Okamoto H, Cervera R, Rodriguez-Reyna TS, Nishimura H, Yoshio T.
  • Journal Title: Autoimmune Dis 2012 Volume: 815753 Pages: 2
• [Journal Article] Clinical analysis of anti-NR2 glutamate receptor antibodies and interleukin-6 with neuropsychiatric systemic lupus erythematosus (2011)
  • Author(s): Sato S, Kawashima H, Hoshika A, Yoshio T
  • Journal Title: Rheumatology Volume: 50 Pages: 2142-4
• [Presentation] Cerebrovascular disease を呈し抗NMDAR2抗体陽性・高サイトカインをきたした小児中枢神経ループス2症例における臨床検討 (2012)
  • Author(s): 佐藤智、河島尚志、星加明徳、吉尾卓
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-27
• [Presentation] 膠原病の難治性病態とアンメットニーズシンポジウム中枢神経ループス (2012)
  • Author(s): 吉尾卓
  • Organizer: 第56回日本リウマチ学会総会・学術総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-26
• [Presentation] The intrathecal production of IL-6, IL-8, IP-10, MCP-1 and G-CSFincrease more highly than the serum production in patients with central neuropsychiatric lupus erythematosus (NPSLE). (2011)
  • Author(s): Taku Yoshio, Hiroshi Okamoto, Kazuhiro Kurasawa, Yoshiaki Dei, Shunsei Hirohata, Seiji Minota.
  • Organizer: American College of Rheumatology 75th Annual Scientific Meeting 2011
  • Place of Presentation: Chicago, Illinois, USA
  • Year and Date: 2011-11-07