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2012 Fiscal Year Final Research Report

The role of microglia under the mechanisms of neuronal damage after seizure in the hippocampus

Research Project

  • PDF
Project/Area Number 22591139
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionTokyo Women's Medical University

Principal Investigator

TAKEMIYA Takako  東京女子医科大学, 医学部, 准教授 (70297547)

Co-Investigator(Renkei-kenkyūsha) TAKEUCHI Chisen  東京女子医科大学, 医学部, 非常勤講師 (70333094)
Project Period (FY) 2010 – 2012
Keywords小児神経学
Research Abstract

I found that Interleukin-1β(IL-1β)produced in microglia stimulated an induction of mPGES-1 in endothelial cells and EP3 receptor on astrocyte under the intercellular mechanisms of neuronal injury after seizure. In addition, IL-1β affected on IL-1Receptor Type1 (IL-1R1) on the astrocyte to increase EP3 induction. On the other hand, IL-1β might regulate constructing a basic structure, suggesting a necessity to investigate the role of IL-1β in detail

  • Research Products

    (12 results)

All 2013 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Microsomal prostaglandin E synthase-1 aggravates inflammation and demyelination in a mouse model of multiple sclerosis2013

    • Author(s)
      Takeuchi C, Matsumoto Y, Kohyama K, Uematsu S, Akira S, Yamagata K and Takemiya T
    • Journal Title

      Neurochem Int

      Volume: Vol.62 Pages: 271-280

    • Peer Reviewed
  • [Journal Article] 睡眠障害とプロスタグランジン2012

    • Author(s)
      竹宮 孝子
    • Journal Title

      加齢研究

      Volume: Vol.3 Pages: 39-44

    • Peer Reviewed
  • [Journal Article] Endothelial microsomal prostaglandin E synthase-1 facilitates neurotoxicity by elevating astrocytic Ca^(2+) levels2011

    • Author(s)
      Takemiya T, Matsumura K, Sugiura H, Yasuda S, Uematsu S, Akira S, Yamagata K.
    • Journal Title

      Neurochem Int

      Volume: Vol.58 Pages: 489-496

    • Peer Reviewed
  • [Journal Article] Prostaglandin E(2) produced by microsomal prostaglandin E synthase-1 regulates the onset and the maintenance of wakefulness2011

    • Author(s)
      Takemiya T
    • Journal Title

      Neurochem Int.

      Volume: Vol.59 Pages: 922-924

    • Peer Reviewed
  • [Journal Article] 覚醒における膜型 PGE 合成酵素(mPGES-1)の作用2011

    • Author(s)
      竹宮 孝子、文沢久美子
    • Journal Title

      不眠研究

      Pages: 61-64

    • Peer Reviewed
  • [Journal Article] Endothelial microsomal prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate.2010

    • Author(s)
      Takemiya T, Matsumura K, Sugiura H, Maehara M, Yasuda S, Uematsu S, Akira S, Yamagata K.
    • Journal Title

      J. Neurosci. Res.

      Volume: Vol.88 Pages: 381-390

    • Peer Reviewed
  • [Presentation] 多発性硬化症における膜型プロスタグランジン E 合成酵素(mPGES-1)の関与2012

    • Author(s)
      竹宮 孝子、竹内 千仙、山形 要人
    • Organizer
      第127回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-20
  • [Presentation] Prostaglandin E(2) produced by microsomal prostaglandin E synthase-1 regulates the onset and themaintenance of wakefulness2012

    • Author(s)
      Takako Takemiya and Kumiko Fumizawa
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-20
  • [Presentation] Endothelial microsomal prostaglandin E synthase-1 facilitates neurotoxicity by elevating astrocytic Ca2+ levels2011

    • Author(s)
      Takako Takemiya, Kiyoshi Matsumura, Kanato Yamagata
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-16
  • [Presentation] Endothelial microsomal prostaglandin E synthase-1 exacerbatesneuronal injury induced by kainate via astrocytes2010

    • Author(s)
      Takako Takemiya, Kiyoshi Matsumura, Hiroko Sugiura, Shin Yasuda, Kanato Yamagata
    • Organizer
      The 29th NAITO CONFERENCE GLIA WORLD
    • Place of Presentation
      神奈川
    • Year and Date
      2010-10-06
  • [Presentation] Moduratory effect of Microsomal prostaglandin E synthase-1 on multiple sclerosis2010

    • Author(s)
      Takako Takemiya, Chisen Takeuchi, Yoh Matsumoto, Kuniko Kohyama, Satoshi Uematsu, Shizuo Akira, Kanato Yamagata, Kumiko Fumizawa
    • Organizer
      第53回日本神経化学会大会、第33回日本神経科学大会、第20回日本神経回路学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
  • [Remarks] ホームページ等 総合研究所ホームページ内に研究成果発表

    • URL

      http://www.twmu.ac.jp/MRI/kenkyubu.html

URL: 

Published: 2014-08-29  

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