2012 Fiscal Year Final Research Report
Pathophysiology and pharmacotherapy in pulmpnary arterial hypertension
| Project/Area Number |
22591180
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokushima |
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Principal Investigator |
HAYABUCHI Yasunobu 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (20403686)
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| Co-Investigator(Kenkyū-buntansha) |
SAKATA Miho 徳島大学, 病院, 特任助教 (80532514)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 肺高血圧 / 血管平滑筋細胞 / イオンチャネル / カリウムチャネル |
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| Research Abstract |
Proliferative smooth muscle cells predominantly express intermediate-conductance Ca2+-activated K+ (IKca) channels.This phenotypic shift in the Kca channel expression pattern gives rise to dramatic alterations in the electrical properties of the cell, which have functional consequences, inpart because of the effect on Ca2+ influx. IKca channel activation contributes to Ca2+ entry in smooth muscle cells andtherefore affect migration and proliferation in some pathophysiologic conditions.
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