2012 Fiscal Year Final Research Report
Diagnosis and new treatment for new subsets of orthostatic dysregulation in children
| Project/Area Number |
22591194
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 起立性調節障害 / 起立直後性低血圧 / 脳血流 / 周波数解析 / 自律神経機能 |
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| Research Abstract |
Orthostatic dysregulation has been reported to show four different subtypes of cardiovascular response to standing. We found two additional subsets, ie, the hyper-response type and the hypo-perfusion type, using a non-invasive beat-to-beat blood pressure measurement and a near-infrared spectroscopy. Among 478 children the percentage of the six subtypes is as follows; instantaneous orthostatic hypotension (22.8%), postural tachycardia syndrome (20.7%), delayed orthostatic hypotension (5.0%), neurally-mediated syncope (1.0%), hyper-response type (9.4%), hypo-perfusion type (5.6%), thus fifteen percent of children with OD showed new subtypes. POTS showed marked orthostatic decrease in vagal modulation of the heart determined by power spectral analysis. Head-up tilt training indicated improvement of orthostatic tachycardia and orthostatic tolerance, suggesting a new useful treatment of POTS.
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Research Products
(54 results)
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[Journal Article] 小児起立 性調節障害診断・治療ガイドラインに対 する評価2012
Author(s)
田中英高,藤田之彦,石谷暢男,梶原荘平,増谷聡,松島礼子,塩川宏郷,竹中義人,汐田まどか,石崎優子,梶浦貢,小柳憲司,本多和雄。
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Journal Title
子どもの心とからだ
Volume: 21巻 1号
Pages: 219-222
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[Journal Article] 小児起立性調節障害診断2012
Author(s)
田中英高,藤田之彦,梶原荘平,竹中義人,村上佳津美,石崎優子,数間紀夫,塩川宏郷,汐田まどか,石谷暢男,飯山道郎,増谷聡,藤井由里,金泰子,松島礼子,神原雪子,東佐保子,梶浦貢,中尾亮太,岡本直之,本多和雄。
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Journal Title
治療ガイドライン
Volume: 21巻 1号
Pages: 215-218
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[Journal Article] 専門医向け小児起立性調節障害診断2012
Author(s)
田中英高,藤田之彦,石崎優子,村上佳津美,梶原荘平,数間紀夫,飯山道郎,竹中義人,金泰子,松島礼子,梶浦貢,神原雪子,中尾亮太,藤井由里,東佐保子,岡本直之。
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Journal Title
治療ガイドライン
Volume: 21巻 1号
Pages: 191-214
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[Journal Article] Japanese clinical guidelines for chronic pain in children and adolescents.2011
Author(s)
Ishizaki Y, Yasujima H, Takenaka Y,Shimada A, Murakami K, Fukai Y, Inouwe N, Oka T, Maru M, Wakako R, Shirakawa M, Fujita M, Fujii Y, Uchida Y, Ogimi Y, Kambara Y, Nagai A, Nakao R, Tanaka H.
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Journal Title
DOI
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