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2012 Fiscal Year Final Research Report

Risk-based diagnostic approach in cardiac imaging

Research Project

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Project/Area Number 22591320
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKanazawa University

Principal Investigator

NAKAJIMA Kenichi  金沢大学, 医学系, 准教授 (00167545)

Project Period (FY) 2010 – 2012
Keywords虚血性心疾患 / 心血管イメージング / 心臓核医学 / 疾患リスク / 多施設研究
Research Abstract

While multiple modalities are available in cardiac imaging, information from imaging and clinical backgrounds were integrated in this study to estimate the patients risk for serious cardiac events. Databases of myocardial perfusion single-photon emission computed tomography were standardized, and parameters derived from fatty acid and sympathetic imaging were standardized. The specific software for standardized measurements was also created. Factors related to the high-risk and low-risk patients were determined by multicenter studies, and the risk-calculation software and risk charts were published. Risk-based diagnostic approach provided essential information for utilizing multiple diagnostic modalities.

  • Research Products

    (34 results)

All 2012 2011 2010

All Journal Article (12 results) (of which Peer Reviewed: 10 results) Presentation (20 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Standardization of meta-iodobenzylguanidine heart-to-mediastinum ratio using a calibration phantom: Effects of correction on normal databases and a multi-center study2012

    • Author(s)
      Nakajima K, Okuda K, Matsuo S, Yoshita M, Taki J, Yamada M, Kinuya S
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 39 Pages: 113-119

    • Peer Reviewed
  • [Journal Article] Cardiac event risk in Japanese subjects estimated using gated myocardial perfusion imaging, in conjunction with diabetes mellitus and chronic kidney disease2012

    • Author(s)
      Nakajima K, Matsuo S, Okuyama C, Hatta M, Tsukamoto K, Nishimura S, Yamashina A, Nishimura T
    • Journal Title

      Circ J

      Volume: 76 Pages: 168-175

    • Peer Reviewed
  • [Journal Article] Cardiovascular events in Japan: Lessons from the J-ACCESS multicenter prognostic study using myocardial perfusion imaging2012

    • Author(s)
      Nakajima K, Nishimura T
    • Journal Title

      Circ J

      Volume: 76 Pages: 1313-1321

    • Peer Reviewed
  • [Journal Article] Wakabayashi H, Taki J, Kinuya S. Cause of apical thinning on attenuation-corrected myocardial perfusion SPECT2011

    • Author(s)
      Okuda K, Nakajima K, Matsuo S
    • Journal Title

      Nucl Med Commun

      Volume: 32 Pages: 1033-1039

    • Peer Reviewed
  • [Journal Article] Quantification of myocardial perfusion SPECT using freeware package (cardioBull)2011

    • Author(s)
      Okuda K, Nakajima K, Hosoya T, Ishikawa T, Matsuo S, Kawano M, Taki J, Kinuya S
    • Journal Title

      Ann Nucl Med

      Volume: 25 Pages: 571-579

    • Peer Reviewed
  • [Journal Article] Semi-automated algorithm for calculating heart-to-mediastinum ratio in cardiac Iodine-123 MIBG imaging2011

    • Author(s)
      kuda K, Nakajima K, Hosoya T, Ishikawa T, Konishi T, Matsubara K, Matsuo S, Kinuya S.
    • Journal Title

      J Nucl Cardiol

      Volume: 18 Pages: 82-89

    • Peer Reviewed
  • [Journal Article] Visual versus quantitative assessment: a new viewpoint for cardiac function using motion tracking method2011

    • Author(s)
      Nakajima K
    • Journal Title

      Circ J

      Volume: 75 Pages: 57-58

  • [Journal Article] Estimation of cardiac event risk by gated myocardial perfusion imaging and quantitative scoring methods based on a multi-center J-ACCESS database2010

    • Author(s)
      Nakajima K, Matsuo S, Okuda K, Wakabayashi H, Tsukamoto K, Nishimura T
    • Journal Title

      Circ J

      Volume: 75 Pages: 2417-2423

    • Peer Reviewed
  • [Journal Article] Normal values for nuclear cardiology: Japanese databases for myocardial perfusion, fatty acid and sympathetic imaging and left ventricular function2010

    • Author(s)
      Nakajima K
    • Journal Title

      Ann Nucl Med

      Volume: 24 Pages: 125-135

  • [Journal Article] Identification of myocardial damage in systemic sclerosis: A nuclear cardiology approach. In: Special issue of vascular disease in systemic sclerosis2010

    • Author(s)
      Nakajima K, Matsuo S, Hasegawa M, Kinuya S, Takehara K
    • Journal Title

      Int J Rheumatology

    • Peer Reviewed
  • [Journal Article] Prognostic value of normal stress myocardial perfusion imaging and ventricular function in Japanese asymptomatic patients with type 2 diabetes2010

    • Author(s)
      Matsuo S, Nakajima K, Yamasaki Y, Kashiwagi A, Nishimura T
    • Journal Title

      Circ J

      Volume: 74 Pages: 1916- 1921

    • Peer Reviewed
  • [Journal Article] The validity of multi-center common normal database for identifying myocardial ischemia: Japanese Society of Nuclear Medicine working group database2010

    • Author(s)
      Nakajima K, Matsuo S, Kawano M, Matsumoto N, Hashimoto J, Yoshinaga K, Taki J, Okuda K
    • Journal Title

      Ann Nucl Med

      Volume: 24 Pages: 99-105

    • Peer Reviewed
  • [Presentation] How to establish the database and standard measurements. International Symposium: Understanding the pathophysiology and new treatment for heart disease using nuclear cardiology2012

    • Author(s)
      Nakajima K
    • Organizer
      第52回日本核医学会総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-10-13
  • [Presentation] I-123 MIBG meta analysis for predicting cardiac death in heart failure: A multi-center investigation in Japan2012

    • Author(s)
      Nakajima K, Nakata T, Matsuo S, Yamashina S, Kasama S, Yamada T, Momose M, Matsui T, Jacobson A
    • Organizer
      59th Society of Nuclear Medicine Annual Meeting
    • Place of Presentation
      Miami Beach Convention Center (USA)
    • Year and Date
      2012-09-13
  • [Presentation] Optimization of iterative reconstruction with attenuation, scatter and resolution corrections in myocardial perfusion SPECT/CT2012

    • Author(s)
      Okuda K, Nakajima K, Yamada M, Wakabayashi H, Ichikawa H, Arai H, Matsuo S, Taki J, Kinuya S
    • Organizer
      59th Society of Nuclear Medicine Annual Meeting
    • Place of Presentation
      Miami Beach Convention Center (USA)
    • Year and Date
      2012-06-13
  • [Presentation] A meta-analysis study for establishing the prognostic efficacy of assessment of cardiac sympathetic innervation assessed by I-123-MIBG imaging in chronic heart failure2012

    • Author(s)
      Nakata T, Nakajima K, Yamashina S†, Kasama S, Yamada T, Momose M, Matsui T,Matsuo S, Travin M, Jacobson A
    • Organizer
      61st Annual Scientific Session of American College of Cardiology
    • Place of Presentation
      McCormick Place (USA)
    • Year and Date
      2012-03-27
  • [Presentation] Estimation of cardiac event risk based on Japanese multicenter prognostic database using myocardial perfusion imaging (MPI): with reference to diabetes mellitus and chronic kidney disease2012

    • Author(s)
      Nakajima K, Matsuo S, Nishimura S, Yamashina A, Nishimura T.
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-03-18
  • [Presentation] 心臓 I-123 MIBGイメージングにおける心縦隔比算出のための半自動アルゴリズム2011

    • Author(s)
      奥田光一、中嶋憲一、細谷徹夫、石川丈洋、小西貴広、松原孝祐、松尾信郎、絹谷清剛
    • Organizer
      第21回心臓核医学会総会・学術大会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2011-06-25
  • [Presentation] 心筋I-123 MIBG 検査に関する多施設共同研究2011

    • Author(s)
      奥田光一、中嶋憲一、桐原ゆみ子、石川丈洋、松尾信郎、滝淳一、絹谷清剛
    • Organizer
      ファントム実験および解析結果について日本核医学技術学会.第81回北陸地方会
    • Place of Presentation
      石川県地場産業振興センター(石川県)
    • Year and Date
      2011-06-18
  • [Presentation] Myocardial metabolism may offer further risk stratification in the management of patients with heart failure2011

    • Author(s)
      Matsuo S, Nakajima K, Kinuya S
    • Organizer
      58th Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      San Antonio Convention Center (USA)
    • Year and Date
      2011-06-08
  • [Presentation] Estimation of cardiac event risk by integrated software of perfusion defect scoring and clinical backgrounds International Conference of Nuclear Cardiology and Cardiac CT2011

    • Author(s)
      Nakajima K, Matsuo S, Okuda K, Wakabayashi H, Tsukamoto K, Kinuya S, Nishimura T
    • Organizer
      Amsterdam RAI Congress Center
    • Place of Presentation
      Netherland
    • Year and Date
      2011-05-18
  • [Presentation] Standardization of cardiac meta-iodobenzylguanidine (MIBG) heartto-mediastinum (H/M) ratio for a multi-center studytility of inter-institutional calibration phantomsInternational Conference of Nuclear Cardiology and Cardiac CT2011

    • Author(s)
      Nakajima K, Okuda K, Matsuo S, Kirihara Y, Ishikawa T, Taki J, Yoshita M, Yamada M, Kinuya S
    • Organizer
      Amsterdam RAI Congress Center
    • Place of Presentation
      Netherland
    • Year and Date
      2011-05-18
  • [Presentation] Evaluation of altered myocardial metabolism may be useful in the management of patients heart failure2011

    • Author(s)
      Matsuo S, Nakajima K, Kinuya S
    • Organizer
      10th International Conference of Nuclear CardiologyAmsterdam RAI Congress Center
    • Place of Presentation
      Netherland
    • Year and Date
      2011-05-18
  • [Presentation] Stress myocardial perfusion imaging for risk stratification of patients with metabolic syndrome: a sub-analysis of the J-ACCESS 2investigation nternational Conference of Nuclear Cardiology and Cardiac CT2011

    • Author(s)
      Takeishi Y, Nakajima K, Nishimura T
    • Organizer
      Amsterdam RAI Congress
    • Place of Presentation
      Netherland
    • Year and Date
      2011-05-18
  • [Presentation] Relationship between stress-induced ischemia and coronary artery atherosclerosis measured by SPECT/CT imaging2011

    • Author(s)
      Matsuo S, Nakajima K, Okuda K, Kinuya S
    • Organizer
      10th International Conference of Nuclear Cardiology
    • Place of Presentation
      Amsterdam RAI Congress Center (Netherland)
    • Year and Date
      2011-05-18
  • [Presentation] 心筋I-123 MIBGイメージングにおける円形心臓ROIの適応2010

    • Author(s)
      奥田光一、中嶋憲一、細谷徹夫、石川丈洋、松尾信郎、小西貴広、滝淳一、絹谷清剛
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Year and Date
      2010-11-13
  • [Presentation] I-123MIBGの心縦隔比の標準化:9施設での校正ファントムによる検討2010

    • Author(s)
      中嶋憲一、奥田光一、松尾信郎、滝 淳一、絹谷清剛、桐原ゆみ子、石川丈洋
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Year and Date
      2010-11-13
  • [Presentation] 減弱および分解能補正による血流分布への影響2010

    • Author(s)
      奥田光一、中嶋憲一、山田正人、荒井弘之、松尾信郎、滝 淳一、絹谷清剛
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Year and Date
      2010-11-13
  • [Presentation] シンポジウム:「心筋SPECTの標準化に向けて」心臓核医学の標準化に必要な視点2010

    • Author(s)
      中嶋憲一
    • Organizer
      第20回心臓核医学会総会・学術大会
    • Place of Presentation
      東京コンファレンスセンター品川(東京都)
    • Year and Date
      2010-06-26
  • [Presentation] J-ACCESS 2 multicenter study in Japan2010

    • Author(s)
      Nakajima K, Yamasaki Y, Kusuoka H, Izumi T, Kashiwagi A, Kawamori R, Shimamoto K, Yamada N, Nishimura T
    • Organizer
      J-ACCESS 2 multicenter study in Japan: Prognosis of asymptomatic patients with type 2 diabetes Annual Meeting of the Society of Nuclear Medicine 2010
    • Place of Presentation
      Salt Palace Convention Center (USA)
    • Year and Date
      2010-06-09
  • [Presentation] Prognosis of patients with coronary artery disease after percutaneous coronary intervention: J-ACCESS subanalysis in patients with early revascularization2010

    • Author(s)
      Nakajima K, Matsuo S, Nishimura T
    • Organizer
      The 74th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2010-03-07
  • [Presentation] Prognostic value of normal stress myocardial perfusion imaging and ventricular function in Japanese asymptomatic patients with type 2 diabetes2010

    • Author(s)
      Matsuo S, Nakajima K, Yamasaki Y, Kashiwagi A, Nishimura T
    • Organizer
      The 74th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2010-03-07
  • [Book] Horizons in World Cardiovascular Research2010

    • Author(s)
      Nakajima K, Nishimura T
    • Publisher
      Nova Science
  • [Patent(Industrial Property Rights)] I-123 MIBG 検査の心・縦隔比算出における縦隔関心領域の自動設定方法2010

    • Inventor(s)
      中嶋憲一、奥田光一、細谷徹夫、石川丈洋
    • Industrial Property Rights Holder
      富士フイルムRIファーマ株式会社
    • Patent Publication Number
      特開2012-78088
    • Filing Date
      2010-09-30

URL: 

Published: 2014-08-29  

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