2012 Fiscal Year Final Research Report
Development of Novel PET Probes for Metabotropic Glutamate Receptor Subtype 1 (mGluR1)
| Project/Area Number |
22591379
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
MING-RONG Zhang 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, プログラムリーダー (80443076)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 放射性医薬品 / 造影剤PETイメージング剤 |
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| Research Abstract |
Metabotropic glutamate receptor subtype (mGluR1) has many important roles on ischemic, pain and epilepsy, etc. In this study, we have developed novel PET probes for imaging of mGlu1 in brain, with potential for imaging the mGlu1 receptor in rodent and primate brains. Of these new candidates, [11C]ITMM is being used clinically for the study of human brain to elucidate the distribution and density of mGlu1 receptor.
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Research Products
(14 results)
