2012 Fiscal Year Final Research Report
Effect of valproic acid and low dose docetaxel for radiosensitivity in esophageal squamous cell carcinoma
| Project/Area Number |
22591380
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMURA Takashi 金沢大学, 医学系, 准教授 (50262580)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 放射線治療学 |
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| Research Abstract |
We evaluated the Effect of valproic acid (VPA) and low dose docetaxel (DTX) for radiosensitivity in esophageal squamous cell carcinoma (ESCC). VPA induced acetylation of histones H3 and H4 in ESCC cells. VPA inhibited the DNA double strand break repair by decreasing Rad51 expression and Ku70 acetylation. VPA enhances ESCC cells radiosensitivity by chromatin decondensation and down regulation of DNA double strand break repair proteins. Low dose (5 nM) DTX induced G1 and G2-M accumulation in ESCC cell, respectively. Low dose DTX (
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