2012 Fiscal Year Final Research Report
Age-related rupture of internal elastic lamina in atherosclerosis: ultrastrucutral analysis of its occurrence and healing.
| Project/Area Number |
22591542
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
OHTSUKA Aiji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50168986)
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| Co-Investigator(Kenkyū-buntansha) |
TAGUCHI Takehito 岡山大学, 大学院・保健学研究科, 教授 (70188134)
MOMOTA Ryusuke 岡山大学, 大学院・医歯薬学総合研究科, 助教 (80263557)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 弾性線維 / 動脈硬化症 / 内弾性板 / 走査型電子顕微鏡 / 血管鋳型法 / 消化法 |
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| Research Abstract |
At first, we newly developed scanning electron microscopy technique using a formic acid digestion with vascular casts, which revealed, in detail, the three-dimensional(3D) architecture of delicate elastic fibers in small vessels. This method could successfully visualized the three-dimensional architecture of elastic fibers in small various sized of blood vessels, even arterioles and venules. Furthermore, the new method revealed the 3D architectures of corrupted internal elastic lamina.
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