2012 Fiscal Year Final Research Report

Involvement of oxidative stress and endoplasmic reticulum stress inthe pathogenesis of cartilage degeneration

Research Project

Project/Area Number	22591659
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Orthopaedic surgery
Research Institution	Kumamoto University
Principal Investigator	HIROSE Jun 熊本大学, 医学部附属病院, 講師 (40433007)
Co-Investigator(Kenkyū-buntansha)	MIZUTA Hirosi 熊本大学, 大学院・生命科学研究部, 教授 (60174025)
Project Period (FY)	2010 – 2012
Keywords	軟骨変性 / 酸化ストレス / 小胞体ストレス / カルボニルストレス
Research Abstract	To clarify the relationship of oxidative stress, carbonyl stress and endoplasmicreticulum stress in the pathogenesis of cartilage degeneration, we evaluated the roleof the three stresses on chondrocyte function and apoptosis. In cultured rat articularchondrocytes, stimulation with or without suppression of each stress regulatedchondrocyte function and apoptosis. These reactions were involved with crosslink of thethree stresses. In the experiment of direct infusion of the inducers of each stress intorat knees, chondrocyte apoptosis and cartilage degeneration were increased; however, noconnections among these stresses could be found

(3 results)