Evaluation of NF-kb decoy transfer using extracorporeal shock wave for arthritis model

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591676
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Chiba University
• Principal Investigator: OCHIAI Nobuyasu 千葉大学, 大学院・医学研究院, 助教 (40400931)
• Co-Investigator(Kenkyū-buntansha): OHTORI Seiji 千葉大学, 医学部附属病院, 講師 (40361430)
• Project Period (FY): 2010 – 2012
• Keywords: 関節病学

Research Abstract

Treatment using nuclear factor-kB decoy (NF-kB decoy) and extracorporeal shock wave therapy (ESWT) were evaluated. Our data showed that ESWT and NF-kB decoy suppressed the inflammation. Furthermore, both treatments would have synergism for the treatment of arthritis model.

Research Products

• [Journal Article] Radial shock waves effectively introduced NF-kappa B decoy into rat achilles tendon cells in vitro (2010)
  • Author(s): Sugioka K, Nakagawa K, Murata R, Ochiai N, Sasho T, Arai M, Tsuruoka H, Ohtori S, Saisu T, Gemba T, Takahashi K
  • Journal Title: J Orthop Res Volume: 28(8) Pages: 1078-83
  • DOI: doi:10.1002/jor.21081
  • Peer Reviewed