Anti-NF-kB reagents for prevention of urinary stone

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591797
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: TOZAWA Keiichi 名古屋市立大学, 大学院・医学研究科, 准教授 (40264733)
• Co-Investigator(Kenkyū-buntansha): KOHRI Kenjiro 名古屋市立大学, 大学院・医学研究科, 教授 (30122047) ; OKADA Atsushi 名古屋市立大学, 大学院・医学研究科, 講師 (70444966) ; HIROSE Masahito 名古屋市立大学, 大学院・医学研究科, 研究員 (70529172) ; HAYASHI Yutaro 名古屋市立大学, 大学院・医学研究科, 准教授 (40238134)
• Project Period (FY): 2010 – 2012
• Keywords: 尿路結石 / アヂポサイトカイン / 転写因子 / 生活習慣病

Research Abstract

The present lifestyle causes lifestyle-related diseases, such as diabetes, hyperlipidemia, hypertension, and arteriosclerosis, through fat accumulation and overweight. In this research, it showed clearly that the gene expression of adipocytokines relates to the morbidity of a urinary stone disease, and proved that the application to medical treatment is possible. Furthermore, the cytokine promotes adhesion molecules and NF-kappa B-RANK- RANKL signal, and so progress of arteriosclerosis. Same signal transduction inquired by considering that urolithiasis formation is also carrying out the same mechanism. The correlation to urinary stone formation of a RANK- RANKL signal transfer system was not able to be proved.NF-kappa B was activated by many extracellular stimuli, such as oxidant stress. Then, activation of inflammatory cytokine and a macrophage was promoted and it was checked that NF-kappa B plays an important role for urolithiasis formation.

Research Products

• [Journal Article] Effect of Adiponectin on Kidney Crystal Formation in Metabolic Syndrome Model Mice via Inhibition of Inflammation and Apoptosis (2013)
  • Author(s): Fujii Y, Okada A, Yasui T, Niimi K,Hamamoto S, Hirose M, Kubota Y, Tozawa K, Hayashi Y, Kohri K.
  • Journal Title: PLoS One Volume: 8 Pages: e61343
  • DOI: doi:10.1371/journal.pone.0061343
  • Peer Reviewed
• [Journal Article] Role of osteopontin in early phase of renal crystal formation: immunohistochemical and microstructural comparisons with osteopontin knock-out mice (2012)
  • Author(s): Hirose M, Tozawa K, Okada A, Hamamoto S, Higashibata Y, Gao B, Hayashi Y, Shimizu H, Kubota Y, Yasui T, Kohri K
  • Journal Title: Urol Res. Volume: 40 Pages: 121-9
  • DOI: doi:10.1007/s00240-011-0400-z
  • Peer Reviewed
• [Journal Article] Mitochondrial permeability transition pore opening induces the initial process of renal calcium crystallization (2012)
  • Author(s): Niimi K, Yasui T, Hirose M, Hamamoto S, Itoh Y, Okada A, Kubota Y, Kojima Y, Tozawa K, Sasaki S, Hayashi Y, Kohri K
  • Journal Title: Free Radic Biol Med. Volume: 52 Pages: 1207-17
  • DOI: doi:10.1016/j.freeradbiomed.2012.01.005.
  • Peer Reviewed