2012 Fiscal Year Final Research Report
Analysis of infectious tolerance in chronic middle ear inflammation with nontypeable Haemophilus influenzae
| Project/Area Number |
22591885
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Masashi 大分大学, 医学部, 教授 (60211314)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 中耳 / 慢性炎症 / インフルエンザ菌 / T 細胞 / 粘膜免疫 |
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| Research Abstract |
Nontypeable Haemophilus influenzae (NTHi) is considered a major pathogen underlying middle ear infection. This study aimed to investigate the dynamics of IL-17 in chronic otitis media induced by NTHi in Balb/c mice. NTHi was injected into the tympanic bulla with Eustachian tubal obstruction. Middle ear effusions and tissues were collected at day 3, 14, 2 month after injection. The concentration of IL-17 in middle ear effusions eleveated significantly during experiments when compared to control. IL-17 producing ・・ T cells and Th17 cells were also increased up to 6 months in the middle ear. Based on these findings, IL-17 producing T cells existed in chronic state of otitis media, and may play some role for modification of chronic inflammation in the middle ear.
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