2012 Fiscal Year Final Research Report
Promyelocytic leukemia tumor suppressor as therapeutic agent for diabetic retinopathy
| Project/Area Number |
22591929
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MITAMURA Yoshinori 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (30287536)
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| Co-Investigator(Kenkyū-buntansha) |
NAGASAWA Toshihiko 徳島大学, 病院, 助教 (00511338)
KATOME Takashi 徳島大学, 病院, 助教 (50464342)
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| Co-Investigator(Renkei-kenkyūsha) |
HARADA Takayuki 公益財団法人東京都医学総合研究所, 視覚 病態プロジェクト, 副参事研究員 (90345306)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 外科 / 細胞・組織 / 生体分子 / 糖尿病 / 臨床 |
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| Research Abstract |
Promyelocytic leukemia tumor suppressor (PML) mRNA expression levels in membrane samples, and the PML protein concentrations in aqueous humor and vitreous fluid samples were significantly lower in PDR patientsthan control patients. We observed a statistically significant inverse correlation between the concentrations of PML and vascular endothelial growth factor in the aqueous humor and vitreous fluid of PDR patients. Taken together, PML may be a good candidate as a diagnostic marker and a therapeutic agent for PDR.
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