2012 Fiscal Year Final Research Report
The function of PKR in differentiation of mesenchymal stem cells.
| Project/Area Number |
22592055
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HANEJI Tatsuji 徳島大学, 大学院HBS研究部, 教授 (50156379)
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| Project Period (FY) |
2010 – 2012
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| Keywords | PKR / 軟骨細胞分化 / 間葉系幹細胞 |
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| Research Abstract |
An involvement of PKR in differentiation of mesenchymal stem cells has not been clarified yet. Our studies revealed that PKR regulated the differentiation of chondrocyte and osteoclast. The PKR expression reflected the differentiational stage of intestinal epithelial cells and stomach cancer cells. These results indicated that PKR played an important role on the differentiation of mesenchymal stem cells. The findings will contribute to better understanding of bone and cartilage associated disease and a discovery of therapeutic target.
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[Journal Article] Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense2012
Author(s)
Irving AT, Wang D, Vasilevski O, Latchoumanin O, Kozer N, Clayton AH, Szczepny A, Morimoto H, Xu D, Williams BR, Sadler AJ
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Journal Title
Immunity
Volume: 36(5)
Pages: 795-806
DOI
Peer Reviewed
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[Presentation] High glucose peritoneal dialysate induce apoptosis through endoplasmic reticulum stress in peritoneal mesothelial cells2012
Author(s)
Nakamata J, Morimoto H, Baba R, Ishimatsu N, Miyamoto T, Kanegae K, Serino R, Kabashima N, Otsuji Y, Doi Y, Tamura M
Organizer
49th ERA-EDTA (European Renal Association- European Dialysis and Transplant Association) Congress
Place of Presentation
Paris (France)
Year and Date
20120524-27
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[Presentation] Pentraxin 3 Expression in a Rat Model of Continuous Peritoneal Dialysis2012
Author(s)
Ishimatsu N, Miyamoto T, Morimoto H, Nakamata J, Baba R, Kanegae K, Serino R, Kabashima N, Otsuji Y, Doi Y, Tamura M
Organizer
49th ERA-EDTA (European Renal Association - European Dialysis and Transplant Association) Congress
Place of Presentation
Paris (France)
Year and Date
20120524-27
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[Presentation] High glucose levels induce endoplasmic reticulum stress in peritoneal mesothelial cells2010
Author(s)
Nakamata J, Morimoto H, Baba R, Miyamoto T, Shibata T, Serino R, Kabashima N, Otsuji Y, Doi Y, Tamura M
Organizer
43rd Annual Meeting & Scientific Exposition (American Society of Nephrology, Renal week 2010)
Place of Presentation
Denver(USA)
Year and Date
20101116-21
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