2012 Fiscal Year Final Research Report
Establishment of periodontal ligament (PDL) cells derived from deciduous teeth and periodontal tissue regeneration with PDL cells.
| Project/Area Number |
22592296
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The University of Tokushima (2011-2012)
Iwate Medical University (2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHISAKI Akira 岩手医科大学, 歯学部, 教授 (20356439)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 小児歯科学 |
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| Research Abstract |
We established clonal cell lines of periodontal ligament cells derived from human deciduous teeth immortalized by hTERT gene transfer. SH 9 cells showed the ability of differentiation into both osteoblasts and adipocytes. Stromal cell-derived factor-1α(SDF-1) has important roles in migration of mesenchymal stem cells and endothelial progenitor cells. We reported that SDF-1 expression in SH 9 cells was regulated by various cytokines.
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