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2012 Fiscal Year Final Research Report

The dynamic function of membrane-mimic bioactive substances

Research Project

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Project/Area Number 22603008
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field ケミカルバイオロジー
Research InstitutionKanagawa University (2011-2012)
Keio University (2010)

Principal Investigator

NAKAMURA Kazuhiko  神奈川大学, 付置研究所, 研究員 (50286647)

Project Period (FY) 2010 – 2012
Keywords天然物化学 / 生理活性物質
Research Abstract

Chemical studies of complanine, an inflammatory substance isolated from a marine annelid, and related bioactive substances, were carried out. The closely related acetylenic amides to complanine were isolated from a plant resource, and the biological properties of these compounds were revealed. And a novel reaction by Grubbs catalyst was developed through analyzing chemical properties of such compounds.

  • Research Products

    (11 results)

All 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Grubbs carbene complex-catalyzed cleavage of allyl vic-diols to aldehydes with a co-oxidant: application to the selective cleavage of huge marine molecules2011

    • Author(s)
      Han, C.; Yamano, Y.; Kakiuchi, F.; Nakamura, K.; Uemura, D.
    • Journal Title

      Tetrahedron

      Volume: 67 Pages: 9622-9626

    • DOI

      doi:10.1016/j.tet.2011.09.002

    • Peer Reviewed
  • [Journal Article] Melanin Biosynthesis Inhibitors from Artemisia dracunculus2011

    • Author(s)
      Yamada, M.; Nakamura, K.; Watabe, T.; Ohno, O.; Kawagoshi, M.; Uotsu, N.; Chiba, T.; Yamaguchi, K.; Uemura, D.
    • Journal Title

      Biosci. Biotech. Biochem.

      Volume: 75 Pages: 1628-1630

    • DOI

      doi:10.1271/bbb.110306

    • Peer Reviewed
  • [Journal Article] Inhibitory effects of bakuchiol, bavachin and isobavachalcone isolated from Piper longum on melanin production in B16 mouse melanoma cells2010

    • Author(s)
      Ohno, O.; Watabe, T.; Nakamura, K.; Kawagoshi, M.; Uotsu, N.; Chiba, T.; Yamada, M.; Yamaguchi, K.; Yamada, K.; Miyamoto, K.; Uemura, D.
    • Journal Title

      Biosci. Biotech. Biochem.

      Volume: 74 Pages: 1504-1506

    • DOI

      doi:10.1271/bbb.100221

    • Peer Reviewed
  • [Journal Article] Neocomplanines A and B, a complanine family isolated from the marine fireworm Eurythoe complanata2010

    • Author(s)
      Nakamura, K; Tachikawa, Y.; Ohno, O.; Suganuma, M.; Kitamura, M.; Uemura, D.
    • Journal Title

      J. Nat. Prod.

      Volume: 73 Pages: 303-305

    • DOI

      doi:10.1021/np900694j

    • Peer Reviewed
  • [Presentation] Melanin Biosynthesis Inhibitors from Plant Resources2011

    • Author(s)
      Kazuhiko NAKMURA
    • Organizer
      ICOB-7 & ISCNP-27: International Conference on Biodiversity and Natural Products
    • Place of Presentation
      オーストラリア・ブリスベン
    • Year and Date
      2011-07-14
  • [Presentation] タラゴンに含まれるメラニン生成阻害物質2011

    • Author(s)
      中村和彦
    • Organizer
      第91回日本化学会春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-29
  • [Presentation] Inhibitory effects ofprenylated phenolic compounds isolated from Piper longum on melanin biosynthesis in B16 cells2010

    • Author(s)
      KazuhikoNAKAMURA
    • Organizer
      学会名: 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem2010)
    • Place of Presentation
      アメリカ・ホノルル
    • Year and Date
      2010-12-19
  • [Presentation] Biological Function ofComplanine and Related Compounds2010

    • Author(s)
      Kazuhiko NAKAMURA
    • Organizer
      2010 International Chemical Congress of Pacific Basin Societies (Pacifichem2010)
    • Place of Presentation
      アメリカ・ホノルル
    • Year and Date
      2010-12-19
  • [Presentation] ヒハツに含まれるメラニン生成阻害物質2010

    • Author(s)
      中村和彦
    • Organizer
      日本ケミカルバイオロジー学会第5回年会
    • Place of Presentation
      横浜
    • Year and Date
      2010-05-18
  • [Presentation] Molecular Mechanism of Complanines, Inflammatory Substances Isolated from a Marine Annelid2010

    • Author(s)
      Kazuhiko NAKAMURA
    • Organizer
      The 21st French-Japanese Symposium on Medicinal and Fine Chemistry
    • Place of Presentation
      京都
    • Year and Date
      2010-05-01
  • [Patent(Industrial Property Rights)] メラニン産生抑制剤及び美白剤2012

    • Inventor(s)
      川越大、山田昌良、千場智尋、中村 和彦、大野修、渡部多恵子、上村大輔
    • Industrial Property Rights Holder
      ファンケル(株)
    • Patent Publication Number
      特許、特開 2012-102063
    • Filing Date
      2012-05-31

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Published: 2014-08-29  

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