2012 Fiscal Year Final Research Report

Rejuvenation of microcirculation in aged rats by young hematopoietic cell transplantation

Research Project

Project/Area Number	22650075
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Nerve anatomy/Neuropathology
Research Institution	公益財団法人先端医療振興財団 (2012) National Cardiovascular Center Research Institute (2010-2011)
Principal Investigator	TAGUCHI Akihiko 公益財団法人先端医療振興財団, 再生医療研究部, 部長 (10359276)
Project Period (FY)	2010 – 2012
Keywords	血管再生 / 造血系幹細胞 / 老化 / 若返り / 脳梗塞 / 腎障害 / 骨髄単核球 / Tie2
Research Abstract	Circulating bone marrow-derived immature cells have been implicated in homeostasis of the microvasculature, and decreased levels of circulating endothelial progenitor cells, associated with aging, correlate with poor clinical outcomes in a range of cardiovascular diseases. We transplanted bone marrow cells from young stroke-prone spontaneously hypertensive rats (SHR-SP) into aged SHR-SP, and found that animals transplanted with bone marrow from young SHR-SP displayed an increase in density of the microvasculature in the periinfarction zone, reduced ischemic brain damage and improved neurologic function.

(5 results)