2012 Fiscal Year Final Research Report
Development of Bio-stimulation Electrode Using Membrane Protein
Project/Area Number |
22650103
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Biomedical engineering/Biological material science
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Research Institution | Tokyo Institute of Technology |
Principal Investigator |
YAGI Tohru 東京工業大学, 大学院・情報理工学研究科, 准教授 (90291096)
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Project Period (FY) |
2010 – 2012
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Keywords | 医用マイクロ・ナノマシン / ギャップジャンクション / 人工脂質二重層 |
Research Abstract |
Tubular membrane protein’s ion permeation function is available for biomedical applications such as cell stimulation devices. However, when considering that those proteins stimulate the multiple cells in parallel, it is not easy to evaluate each function to the cell at the same time by electrical measurements. Therefore, we propose the use of ion sensor to evaluate the protein’s electrical properties on the basis of its fluorescence images. In this study, we introduced target proteins into an artificial lipid bilayer membrane where the ion concentration gradient exists. Then, we observe fluorescence images and record electrical properties of the membrane.
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